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Role of the SAGA co-activator complex in transcription during cell differentiation in mammals – SAGA-Retina
SAGA is a coactivator complex with histone acetyl transferase activity, deubiquitinase activity, and can bind the TATA-binding protein, TBP. Using novel approaches, we recently discovered that SAGA is indispensable for the expression of the majority of genes in yeast. Little is known about the function of SAGA in mammalian cells. This project aims at better understanding the function of the SAGA complex for RNA polymerase II transcription in mammalian cells.
Dissecting Type Four Pili in Action – T4PNanoAction
Type IV Pili (T4P) are filamentous cell surface structures present in numerous bacterial pathogens including Neisseria meningitidis and highly involved in virulence. A nanomachinery anchored in the bacterial wall constantly assembles and disassembles T4P. The aim of this proposal is to dissect the different steps leading to a functional T4P nanomachinery by combining innovative in vivo cross-linking mass spectrometry (XL-MS) and cryo-Electron Microscopy (cryo-EM) approaches.
The Behavioral and Computational Nature of Range Dependent Decisions – RANGE
ndividual decision-making is at the root of major societal, health, environmental and individual issues. Most of our decisions entails uncertainty and risk regarding their consequences and compels us to engage in permanent arbitrage. In this outlook, it is quite common to notice that our current financial decisions are strongly sensitive to options available in the current context (even if they are not relevant) and to the conditions in which we previously earnt or lost money. In this regard, so
EVolution of CO-infecting PAthogens in Rice – EVCOPAR
Co-infection corresponds to the context of infection of the same plant by various pathogen species or genotypes, an increasingly common phenomenon. It is recognized to modify the outcome of each infection. Such effects evidenced at the plant level may further translate into population scale effects, with important epidemiological and evolutionary consequences of multiple infections, but the latter was scarcely investigated.
Integration of Microseism and Coda Correlations as a New Dataset for Deep Earth Seismic Imaging – TerraCorr
How to use in a timely manner the wave field produced by major oceanic events and the long-lasting reverberations produced by large Earthquakes to illuminate the deep Earth?
Mixed (Anti)Aromaticity, Unorthodox Interactions and Topologies – MixAr
The MixAr project aims at expanding the knowledge concerning antiaromaticity. Our approach explores the mixing of (anti)aromaticity, unorthodox interactions and topologies following 3 main axes: the study of “mixed (anti)aromaticity” with antiaromatic species forced to “interact” with each-others or with aromatic ones. Probe “unorthodox interactions” of molecules with antiaromatic 4n p-system to target antiaromatic catalysis. Access to “[4n+2] Möbius antiaromaticity”, of fundamental interest.
Peptidergic control of pain and emotions: relaxin-3/RXFP3 modulation of descending pathways – RELAX
La douleur chronique est un problème de santé publique avec d’importantes conséquences économiques. La douleur et l’anxiété ou la dépression sont les symptômes les plus fréquents en consultation et sont souvent associés. Malgré leur prévalence, les syndromes douloureux chroniques et leurs comorbidités demeurent un enjeu clinique mal maîtrisé.
Domestication as a step towards reproductive isolation – DomIsol
Genetic exploitation of wild relatives in crop improvement is a key alternative strategy to the massive use of inputs, and promotes the sustainability of agroecosystems. It is however conditioned by cross compatibilities between wild and domesticated forms, and fertility of the resulting progenies. <br />The DOMISOL project aims at characterizing the extent and molecular nature of reproductive barriers between wild and domesticated forms, and at investigating the underlying evolutionary processes.
Thioacid / Azide Ligation Applied to Nucleic acids as a new tool for chemical biology – TALAN
The TALAN project aims to explore the potential of the thioacid / azide ligation (TAL) (and in particular the sulfo-click reaction, involving a thioacid and a sulfonyl-azide function) as a new DNA templated bioorthogonal chemical ligation in order to provide a new tool for the detection and quantification of nucleic acids in a biological medium.
Decoding and monitoring operators’ cognitive states – BLADE
With autonomous vehicles and automated aircraft, humans interact with increasingly autonomous systems. But how can we ensure that these interactions remain safe, efficient, and adapted to human abilities? This project aims to better understand the cognitive states involved in interactions with automated systems, in order to design technologies that enable safer and more optimal interactions.
