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Chromatin remodeling in regulation of chromosomal Crossing-Over and seed production – ChromCO
Crossing-Over (CO) during meiosis is a fundamental process ensuring sexual transmission of genetic material to next generation and meanwhile generating diversity within species by creating new chromosome/allele combinations. Understanding of the mechanisms that regulate CO frequency has great interest in basic research as well as in application in breeding.
In silico models of drug transport to enhance personalized medicine – IMOTEP
Decoding Transporter Mechanisms for Better Treatments
Deciphering the mechanisms involved in the hyperaccumulation of alkaline earth metals by cyanobacteria – HARLEY
By coupling biochemistry, genetics and microscopy, we intend to identify the molecular actors and mechanisms involved in the formation of intracellular calcium carbonates by some cyanobacteria. This biomineralization process is particularly interesting since it results in a massive intracellular accumulation of earth alkaline elements and offers promising perspectives for remediating pollutions by some radioactives pollutants
Redox regulation of plant HDAC activity in response to climate change – REPHARE
Whether and how histone deacetylase activity is regulated by redox during plant response to high temperature
Morphogenesis, organization and functions of liquid viral factories formed by Mononegavirales – LiquidFact
Infection of the cell with the rabies and measles virus induces the formation of viral factories (VF) that house the synthesis of viral RNAs. VFs are liquid organelles formed by phase separation. We want to characterize the composition and organization of UVs; identify the molecular bases behind the phase separation; explore the link between UV, innate immunity and the cellular translation machinery; and understand how virions leave the UV.
Individual muscle Coordination strategies and their role in the development of musculoskeletal disorders – COMMODE
Our primary testable hypothesis is that each individual has unique muscle coordination strategies that will have specific mechanical effects on his/her MSK system. As such, some strategies would make people more at risk of developing MSK disorders than others.
ARTificial Intelligence-based Cloud network control – ARTIC
In recent years, computer networks have become more complex with an increasing diversity of devices and increased traffic dynamics. One solution to deal with this situation is Knowledge Defined Networking (KDN), where machine learning (ML) and artificial intelligence (AI) are combined with SDN / NFV and network monitoring. According to this paradigm, we aim to develop an AI framework capable of learning new efficient network control algorithms.
Spectral Superdiffusive Phonon Sensor – SPiDER-man
SPiDER-man is devoted to the development of a new instrumentation to probe ballistic-diffusive transfer in nanostructured semiconductors. Over the past decade, rapid improvement of experimental techniques devoted to nanomaterial characterization has arisen. Yet, if those approaches allow spectacular temporal or spatial resolution of heat transfer at nanoscales, they can scarcely describe the ballistic-diffusive regime that exists when length scale and energy carriers mean free path are similar.
Approximate Bayesian solutions for the interpretation of large datasets and complex models – ABSint
This project is motivated by branches of applications<br />where large data sets and complex models represent a genuine challenge: population genetics and phylogenetic analyses, neuroscience and astrostatistics.The expected impacts of the project are two-fold: (1) scientific impacts for the developments of sound statistical tools to analyse massive datasets and complex models and (2) search for approximate solutions to analyse more advanced data structure.
Nanoscale thermal sensing using hybrid diamond sensors – THESEUS
THESEUS project is geared towards the disruptive development of hybrid nano-thermometers, surpassing the performances of present nanoscale temperature probes, by providing sensitivities in the sub-mK/vHz range and high spatial resolution down to a few tens of nanometres, while operating over a broad range of temperature (200 K – 600 K) and in various environments including biological media.
