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Forms of life in the megapolis: Miletus in the longue durée – MegaMil
A social archaeology on a large ancient city
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold – PhotoChiraPhane
Synthesis and applications of planar chiral photoredox catalysts based on a [2.2]paracyclophane scaffold
Electrochemically promoted tyrosine-click-chemistry for protein labelling – E-CLICK
Luminol derivatives provide a selective modification of proteins: A user-friendly eY-click approach for peptides and proteins bioconjugations
New selective Inhibitors for deciphering Lipid metabolism and virulence in M. tb – LipInTB
Tuberculosis (TB) caused by the pathogenic bacterium Mycobacterium tuberculosis (M.tb), is the deadliest infectious disease worldwide. Treating TB takes a minimum of 6-9 months. The emergence of drug resistant strains amplifies the incidences of TB, mainly resulting in failure of treatment and death. There is thus an urgent need for novel therapeutic targets and approaches.
Genome-wide mapping of G4-ligand binding sites at single-base resolution – NEMESES
Development of chemical biology tools to unlock G-quadruplex DNA secondary structure functions in DNA biology. This project aims to finally unveil G-quadruplex formation and accessibility during the different phases of the cell cycle and their role in regulating replication, transcription, translation, and DNA repair.
Implication of pesticides in the decline of avian flagship species in farmland – PestiStress
Comprendre les effets sublétaux des pesticides et leur implication dans le déclin de l’avifaune en milieu rural
Assessments of vulnerability of mature and secondary forests to climatic water stress in Southeast Asia – CWSSEA
The overarching aim of this study is to estimate canopy transpiration and evaluate its variations with climatic conditions, such as atmospheric humidity and soil moisture in primary and secondary forests of Southeast Asia. This project also investigates species-specific responses to water stress by assessing tree hydraulics and stomatal conductance, which will provide a mechanistic understanding of the trees’ ability to conduct water from soil and uptake carbon from the atmosphere.
Mechanisms of intestinal immune response initiation in Peyer's patches – PHAGOMIC
Many emerging pathologies arise from a loss of symbiosis with the microbiota. Dissecting host-microbiota relationship in the gut is therefore critical to define new therapeutic approaches. However, the role of Peyer’s patches (PP), the main immune inductive sites of the gut, in shaping this relationship remains elusive. This project studies the role of the interaction between microbiota and PP phagocytes in intestinal immunity.
3D printed customized composite cement for jaw repair – GIJAW
In children, the interrupted bony loss (IBL) of jaws is mainly caused by malformation as cleft lip or palate at the maxilla. Jaw bone repair is very challenging due to some clinical specifications (complex shape of the defect, risk of infection in oral cavity, specific mechanical properties). Positive functional and aesthetical outcomes can be difficult to achieve. Autologous bone grafting, is the “gold standard” but this can add significant morbidities such as scarring and chronic pain.
Enhancing the Quality and the Level of Internal Protections of Shell Eggs – EQLIPSE
The EQLIPSE project is positioned in the context of extension of the production period of laying hens. In particular it aims to study the consequences of this extension on the quality and natural defenses of eggs and to identify levers to control internal alterations induced by hen age and egg storage conditions.
