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Prediction of enzyme function is a notoriously difficult problem with promising biotechnological impact. Here, we tackle this problem by studying both molecular mechanisms and evolutionary properties of a class of enzymes that are involved in the ubiquinone biosynthesis pathway. To that end, we propose an interdisciplinary approach consisting in confronting bioinformatics studies in evolution (comparative genomics), biophysical models of molecular dynamics and biochemical experiments.
IntpTN3, a unique RecA-independent homology-directed recombinase: mechanism, structure, partners and applications – IntpTN3
(1) Characterization of the enzymatic activity of homologous recombination in vitro of hybrid enzymes. (2) Isolation and characterization of potential protein partners of these enzymes. (3) Use of these enzymes in homologous intact DNA recognition assays. (4) Resolution of the three-dimensional structure of these enzymes.
Single metal atoms can be present in many supported catalysts (including commercial ones) in combination with metal particles, and have certainly played a role in many catalytic processes, but they have rarely been recognized as active sites.<br />The project aims to develop a new generation of catalysts, combining in a controlled manner isolated atoms and metallic particles, in order to achieve cooperative catalysis.
Although the growth of collaborations is a major current trend in the life sciences, little is known about how they influence the working practices of researchers and their partners. <br />COLLAB² aims to provide a broad and in-depth view of these collaborations, based on a study of three structures where they play a major role: «zones ateliers« (ZA), human-environment observatories (OHM) and biosphere reserves (BR).
Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social communication and the presence of restricted interests and stereotyped behaviors, with a current prevalence estimated at around 1 in 100 children. Today, more and more children with ASD have access to schooling (National Disability Conference, 2016). However, the challenge of inclusive schooling is still far from being met.
Catching, modelling and understanding Slow Slip and Seismic Swarms along the Andean subduction in Ecuador, Peru and Chile
We hypothesize that exogenous provision of LXA4 could dampen excessive inflammation in pulpitis and peridontitis. The specific goal of this project is to evaluate the potential benefits of a new Biphasic Microgel (BPMG) as lipoxin A4 (LXA4) delivery system. This functionalized BPMG aims both to modulate inflammation and to promote tissue repair or regeneration in pulpitis and periodontitis
Last mile delivery concerns the last stage of a transport system, from wholesale transport to the delivery to final customers. Because of its synchromodal aspect (several modes of transport subject to synchronization constraints), it is the nightmare of logisticians, especially in urban areas. This project aims at designing advanced optimization algorithms to plan transports in such synchromodal networks.
Solar thermochemical conversion of CO2 and water into fuel using non-stoichiometric oxygen-exchange redox materials – SUNFUEL
The diminution of greenhouse gas emissions from intense utilization of fossil resources requires developing novel sustainable and environmentally-friendly processes. The SUNFUEL project aims to develop an innovative solar process for both hydrogen production from water-splitting and CO2 valorization.
The evolution of extended phenotypes and associated signals in animals : weaverbirds’ nests and sexual selection as a case study – EXTENDEDPHENOTYPE
Extended phenotypes are traits produced outside the body of the individual which carries the genes coding for their expression. While the evolution of many extended phenotypes may have initially been favoured by their protective function, many appear also to serve as sexual signals. We propose to work on one of the most spectacular and diverse radiations of extended phenotypes, the intricate and complex nest architectures of weaverbirds (117 species).