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Role of cAMP signalosomes in cardiomyocyte senescence and age-associated heart failure
The increase in longevity is associated with a wider prevalence of heart failure with preserved ejection fraction (HFpEF). While the incidence of HFpEF in terms of mortality is constantly growing, treatments remain unsuccessful because of insufficient knowledge on the mechanisms of cardiac ageing. In an original approach, our consortium proposes to develop and share appropriate models to better understand HF in the context of ageing.
Effect of non-nutritive sweeteners on vascular function: deciphering the role of the T1R sweet-taste receptors
Effect of non-nutritive sweeteners on vascular function: deciphering the role of the T1R sweet-taste receptors.
Redox modulation of rhodium-catalyzed nitrene insertions into C(sp3)-H bonds
We plan to design new dirhodium(II) complexes in order to develop a more efficient and subsequently enantioselective intermolecular amination of C(sp3)-H bonds in the context of sustainable chemistry. Our approach will be based on a mechanistic study from the point of view of the design of the catalysts, and the influence of the electronic properties of the ligands on their efficiency, selectivity and stability.
Multimedia archives enhancement: multimodal machine comprehension of language for new intelligent interfaces of scientific and cultural mediation
ARCHIVAL : Valorization of multimedia archives <br />Multimodal automatic language understanding for new intelligent interfaces of mediation and knowledge transmission.
The practice of sustainable mobility in Latin American cities: a comparative study of Bogotá (Colombia) and Lima (Peru)
Practices of sustainable mobility in Latin American cities: a comparative study of Bogotá (Colombia) and Lima (Peru)
Ignition Combustion Explosion Environment and Energetic Materials
Contribution to the understanding of energetic systems, both explosive and propulsive:<br />- Optimization of materials and designed systems,<br />- Prediction of the performances of new compositions under current and future environmental constraints (REACH).
Implementing FAIR principles for Theia/OZCAR in situ data information system
Implementation of FAIR principles in Theia/OZCAR, the national inter-agency information system on land surface research data
Fungal communities associated with marine plastic waste and their bioremediation potential
Plastics debris pervades in our oceans and freshwater systems at an increasing accumulation rate. While identifying the major sources of plastics are critical, greater investigations on the plastic microbiome to characterize the whole microbial communities appear also essential. The major aim of MycoPLAST is thus to highlight specific microbial communities, and more precisely fungal communities, able to degrade plastics.
Foundations of (Boolean) automata networks
Relations between syntactic and semantic properties of automata networks, intrinsic simulation, and complexity
Resilience of Interconnected Infrastructures and Systems
The RESIIST project addresses the issues of assessing the resilience of critical infrastructures. It is based on the following findings:<br />-The environment of critical infrastructures and the needs of stakeholders are continuously changing;<br />- Organizations are increasingly interconnected and interdependent;<br />-Risk situations are multiplying;<br />-Diversification of the disaster situation: Risks do not spare any structure and the spectrum of consequences is wide.
