Composite Polysaccharide Hydrogels for the 3D-printing of Shape-Morphing Biomaterials – PolyMorphInk

The design of multifunctional hydrogel systems that combine biocompatibility (hosting of cells), processability (3D printing) and actuation (controlled shape-morphing ability), is a key issue for the future development of tissue engineering. In this context, the PolyMorphInk project proposes to conceive and study a new class of composite materials (inks) by combining, in solution, a crosslinkable polysaccharide matrix, orientable rigid microfibers and a cell population. The chemistry and physicochemical properties of these inks will be tailored to allow for their extrusion in 3D and their postprinting immobilization by photocrosslinking. These inks will be used to create hydrogel constructs containing oriented microfibers. In aqueous media, these structures will swell anisotropically and undergo a shape transformation that will be programmed by the orientation of the embedded fibers. This controlled deformation will be guided towards the production of cell-laden sophisticated architectures that will accurately mimic the intricate and dynamic structure of living tissues.