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A new Fragment-based Approach for inhibition of hk3 and matriptase, two up-regulated serine proteases implicated in tumor progression – FragSPIN
Creation of an experimental pipeline dedicated to the generation of new promising inhibitors of serine protease with therapeutic interest in malignant breast and prostate cancers. The integrated platform combines protease production, parallel inhibitor syntheses and inhibition screening.
A new Generation of dRugs for ALzheimer’s disease based on in vitro and in silico experiments of beta-amyloid oligomers and in vivo tests – GRAL
Alzheimer's disease is affecting more than 24 million people worlwide and represents a 1000 billion dollars cost to our society. Thus far, no disease-modifying treatments exist.
A new generation of light sheet microscope: mesofluidics and artificial assistant – Phy-ASA2018
SPIM in terms of photonic microscopy with novel features that we identify as the future of biology and
A new medical device to reduce the urinary lithiasis recurrence – URITRACK
and long-term prevention) is the main innovative feature of the proposed system. The second point is that
A new non-human primate model for translational brain research – Marmobrain
their brain is lissencephalic while keeping key features of the primate brain. To benefit from these advantages
A new prototype of fast-heating oven dedicated to roc magnetism investigations – FUReMAG
A new prototype of fast-heating oven dedicated to rock magnetism investigations
A new tool to deliver epigenetic targeted therapeutics in Multiple Myeloma. – ETTMM (Epigenetic Targeted Treatment of
Identification of biomarkers to predict the sensitivity of myeloma cells to DNMTi and HDACi. <br />Understand the molecular mechanisms associated with the anti-tumor activity of epigenetic-based treatment to define the most efficient therapeutic combinations.
A novel PERspective on microTUbule Regulation – APERTuRe
Recent experiments have shown that microtubules do not only grow by elongation and shortening at their tips, but also have a dynamic shaft, where tubulin dimers can leave an integrate the lattice. This project aims at characterizing the shaft dynamics and its underlying mechanisms.
A novel, integrated approach to the mechanisms and dynamics of episodic memory: from genes to cells and neural network properties. – MolCellCog
The objective of the project is to understand how the dynamic activity of specific neurons and brain mechanisms of plasticity lead to the formation of memories of past experineces and how these memories are reorganized with time.
A premotor disease signature for ALS – premodiALS
control subjects will guide our analysis to identify features in the PGMC fingerprint that have the best d