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Elucidation of the metabolism of undecaprenyl phosphate, a key lipid for bacterial cell wall polymers biosynthesis – BACTOPRENYL
The present project aims at the complete elucidation of a «black box« of bacterial metabolism that, surprisingly, has not been investigated in great detail up to now: the biosynthesis and recycling of undecaprenyl-phosphate (C55-P), an essential carrier lipid that is required for the synthesis of various cell wall components such as the peptidoglycan.
Iron Sulfur cluster biogenesis under stress conditions – FeStreS
the mechanistic, physiological and evolutionary features of the processes used to insert sulfur into biological
Heterospecific non self recognition in filamentous fungi : from receptors to the cellular response – Mykimun
Identification of filamentous fungi immune receptors and description of the cellular mechanisms expressed in response to pathogens.
Organizational principles of interareal cortical networks – Core-nets
of the network fails to capture its specific features. Hence determining the specificity of the cortical [...] and to better apprehend important algorithmic features of the network. (iii) We will address whether [...] be that in primates transient connectivity is a feature of the prefrontal cortex? Here we will examine
Rfx6 in pancreatic and intestinal endocrine cell differentiation and function – RFX-PancInt
diabetes. Our goals are to assess the clinical features associated with the mutation to define a causal
Micro and Nano-Optomechanics To the quantum Regime – MiNOToRe
demonstrate optomechanical squeezing, with unique features such as a frequency-dependent squeezed quadrature [...] optomechanical crystal with unique on-chip integration features, will be investigated as well and used to cool
Nutrient sensing in plants – NUTSE
The general goal of this project is to identify the mecanisms used by plant to perceive their mineral environment.<br />
Functional genomics through transposon-mediated mutagenesis to unravel virulence gene regulation in Plasmodium falciparum – PlasmoPiggyBac
Plasmodium falciparum, which infects up to 300 million people causing more than two million lives each year, undergoes antigenic variation to establish persistent blood stage infection. The var gene family expresses the major virulence adhesion surface molecule causing severe malaria. We aime to identify factors associated with mono allelic var expression. To achieve this goal, we are creating a transposon-mediated mutant library to identify mutants affected in virulence gene regulation
Inhibition of Mucus Hypersecretion In COPD Exacerbation – IMHICE
Inhibit bronchial mucus hyper-secretion of these patients thereby reducing the risk of pulmonary infections and lung injury.
Techniques of Analysis Pending for Authority allocation in Systems of systems – TAPAS
The aim of the project is to elaborate an assessment and analysis process of different men-machines cooperation configuration in order to understand key issues and bootle necks in operation of future systems featuing high level of autonomy