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Human colonic organoids as a model to study SARS-CoV-2 variants infection – Organovir
New SARS-CoV-2 variants raised particular concerns worldwide due to their high transmissibility rates. The rapid emergence of such variants highlights the urgent need to develop highly relevant and standardized experimental models to study critical aspects of SARS-Cov-2 variant infection and replication but also to screen therapeutic candidates. In this respect, human intestinal organoids have emerged as a valuable model to study host-pathogen interactions, including SARS-CoV-2 infection.
Human intestine biomimetic model to test the impact of microbiota products during SARS-CoV-2 infection – COVIDMicroGutModel
Several lines of evidence reported that the gastrointestinal (GI) tract is targeted by SARS-CoV-2. GI symptoms occur in 15 to 60% of the cases and are associated with severe forms of the infection, and SARS-CoV-2 RNA is present in the stools of infected patients. However, the role played by the intestine during COVID-19 and whether this organ is important for the viral transmission and for downstream inflammatory response is not yet understood
Identification of early biomarkers of the response to corticosteroid therapy in COVID-19 patients. – CortiCoV
SARS-CoV-2 is the human coronavirus that caused the pandemic that began in Wuhan, China at the end of
Involvement of circulating fibrocytes in pathophysiology and prognosis of COVID-19 pneumonia – FIBROCO
High circulating levels of fibrocytes are correlated to an unfavourable outcome during acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis. COVID-19 pneumonia shares common histological and inflammatory features with ARDS. We aimed to determine the involvement of circulating fibrocytes during the course of COVID-19 pneumonia, and to assess if fibrocytes could be a prognosis biomarker.
Modulation of SARS-CoV-2 cell entry – COVENTRY
COVID-19 pandemic is due to the SARS-CoV-2 coronavirus that infects human cells through binding of its
New Soidarity and Resilience in times of crisis – NEOSOILID-R
health, economic and social crisis caused by the coronavirus epidemic. We will focus on “third places” and
Pre-pandemic SARS-CoV-2 natural immunity in Africa and South-East Asia – PRECOV_
Almost two years after the emergence of COVID-19, significant regional differences in terms of morbidity persist, showing in particular lower incidence rates in some regions of Africa or Asia. The work reported here aims to test for a pre-pandemic natural immunity among populations in Africa and South-East Asia, and a suspected SARS-CoV-2 original antigenic sin.
Roles of type I interferons and plasmacytoid dendritic cells in Covid19 – RIPCOV
In order to understand what causes severe cases of Covid19, and thus improve their medical management, it is essential to better understand the natural history of this disease caused by the coronavirus SARS-CoV2.
SARS-CoV-2 transmission in Food Processing Plants - Emphasis on meat processing plants – SACADA
Circulation of SARS-CoV-2 in meat processing plants