RADIation-induced neurOtoxicity assessed by spatio-temporal modelling combined with Artificial Intelligence after brain raDiothErapy – RADIO-AIDE
RADIO-AIDE is a multidisciplinary project that aims to develop advanced spatio-temporal models and new Artifical Intelligence tools for brain Magnetic Resonance Imaging (MRI) data processing to : a) generate new knowledge about the underlying neurotoxic mechanisms implied in the initiation and temporal progression of cognitive dysfunctions following brain radiotherapy (RT) and the radioresistance of targeted brain structures, accounting for the tumor-response status as contextual data; b) predict individual cognitive impairment at early stage after brain RT to set up mitigation measures to preserve the quality of life for survivors; c) provide to clinicians a usable academic tool to perform an automated processing of MRI data acquired in clinical routine, from the longitudinal extraction of clinically relevant image-based biomarkers. The project will be guided by the rich and multimodal data from the EpiBrainRad cohort including patients treated by RT for a high grade glioma.
Project coordination
SOPHIE ANCELET (Institut de Radioprotection et de Sureté Nucléaire - Pôle Santé Environnement - Direction Santé)
The author of this summary is the project coordinator, who is responsible for the content of this summary. The ANR declines any responsibility as for its contents.
Partner
IRSN PSE-SANTE Institut de Radioprotection et de Sureté Nucléaire - Pôle Santé Environnement - Direction Santé
PIXYL
DMU APHP ORPHé DMU APHP.Sorbonne :Oncologie Radiothérapie Soins Palliatifs Hématologie Clinique
CB Centre Borelli
Inria GRA Inria Grenoble Rhône-Alpes
INSERM-GIN Institut national de la sante et de la recherche médicale (INSERM) - GRENOBLE INSTITUT DES NEUROSCIENCES (GIN)
ICANS Institut de cancérologie Strasbourg Europe
ICM Institut du cerveau et de la moelle épinière
Help of the ANR 774,886 euros
Beginning and duration of the scientific project:
March 2022
- 48 Months
