Projets financés

Acute Myocardial Infarction, commonly known as a heart attack, is one of the leading causes of death globally, and the cost of healthcare for patients with this type of heart disease is estimated to be in the billions of euros annually. Recent evidence highlights the instrumental roles of the inflam

Did you know that millions of people in Europe are living with heart failure, leading to millions of hospitalizations every year? One type of heart failure, called HF with preserved ejection fraction (HFpEF), affects half of all heart failure patients. Among these patients, a condition called cardia

At least half of all patients with heart failure primarily suffer from increased stiffening of the heart and impaired cardiac relaxation, rather than contractile dysfunction. The incidence of this form of heart failure, known as heart failure with preserved ejection fraction (HFpEF), steadily increa

Heart Failure with preserved Ejection Fraction (HFpEF) is a type of heart failure where the heart muscle pumps blood less efficiently than it should, even though a normal amount of blood is being pumped out with each heartbeat (as measured by the ejection fraction). This can lead to symptoms like fa

Atrial fibrillation (AF) is a prevalent heart rhythm disturbance (arrhythmia) affecting the upper chambers of the heart (atria). Heart failure (HF) is a severe medical condition associated with pumping dysfunction of the lower heart chambers of the heart (ventricles). AF and HF are two medical probl

Rapid exacerbation of heart failure, better known as acute decompensated heart failure, is associated, despite current medical treatments, with a high morbi-mortality. The incoherent patient and/or treatment stratification, due to the absence of reliable prognostic bio-markers reflecting not only th

Heart Failure (HF) is a syndrome that affects up to 15 million of Europeans, and it commonly occurs in patients affected by other cardiovascular risk factors, including obesity, diabetes, kidney disease and elevated blood pressure. Half of these HF patients suffer from stiffening of the heart, a syn

Inflammation is part of our normal immune response, being important in preventing and fighting infections. However, an inflammatory response that is too strong or lasts too long can lead to tissue damage. Normally, our body generates a special counter-reaction that ensures that this inflammation sto

Acute cardiovascular syndromes (ACS) are the main cause of death in Western society and are caused by atherosclerosis. Intraplaque hemorrhage is a key characteristic of an unstable atherosclerotic plaque at risk for rupture. We propose here that therapeutic approaches to prevent the incidence of int

The heart is a unique organ that performs an incessant work to pump blood throughout the body. For this massive effort, it requires a very high supply of energy. Mitochondria are small components of the cells responsible for the production of energy. To produce energy, mitochondria from cardiac cell