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A Phase I/II clinical study of an innovative neuroprotective and remyelinating compound in Multiple Sclerosis patients: translational phase of the MS-Repair project. – Translate-MS-Repair
5), along with the collaboration of CHU de Rennes and CHU de Reims (Partners 3 and 4). The Transl [...] lead to the premature death of these two cell types, this death resulting in progressive loss of function
A new therapeutic strategy to combat metabolic complications of obesity : the inhibition of fat cell lipolysis – ObeLip
of obese individuals has led to an explosion of type 2 diabetes and cardiovascular diseases. Insulin [...] of adipokine production, signaling lipid species, de novo lipogenesis and, using novel mouse models, to
A novel System for the Characterisation of Agregates and Flocs in highly concentrated rivers (SCAF) – SCAF
No instrument can measure fine sediment settling fluxes during flood events. While this variable is of upmost importance for numerical modelling we will develop and apply a System for the Characterisation of Agregates and Flocs (SCAF) in various natural environments and in the laboratory.
Adaptation strategies and bio-economic regulations in fragile environment: the role of the "desert kites" – GLOBALKITES
GLOBALKITES focuses on defining variability and functionality of major archaeological stone-made structures called «desert kites«. Often considered as hunting traps, the kites could have been also used for animal domestication. In a broader spatial context (from Arabia to Caucasus) and temporal one (from the Neolithic to present), we propose an interdisciplinary approach at the crossings of anthropology, geomatics and archaeological sciences.
Adaptation to darkness and food scarcity of independent populations of Astyanax mexicanus blind cavefish: a comparative transcriptomic approach of the underlying molecular mechanisms. – BLINDTEST
BLINDTest will take advantage of the possibilities offered by second generation sequencing technologies to describe transcriptome-wide the genetic polymorphism that arose within and between natural populations of a vertebrate species presenting populations living in radically different environments. We will then further test functionally the adaptive nature of observed genetic changes through a functional approaches
Advance GAs Turbine for COgeneration – AGATCO
Propose and validate a technical solution for cogeneration from wood biomass by the innovative concept of a ceramic micro gas turbine with an integrated electric generator, the whole system being integrated into a pellet boiler. The strategic objective is an electrical efficiency of about 28-30% and the total efficiency of over 90%.
Analysis of pharmaceutical counterfeits using terahertz technology – AlyPOTEC
Analysis of pharmaceutical falsifications and counterfeits by terahertz technology
Annotation de données visuelles avec des descriptions sémantiques – ViSen
UK), Institut de Robòtica i Informàtica Industrial (IRI, Spain) , Ecole Centrale de Lyon (ECL, France) [...] prepared to handle hetereogeneous documents. The new type of content demands the development of new efficient [...] representations of visual content and object/scene type models derived from semantic representations of
Artificial gauge fields on neutral atoms – AGAFON
The remarkable advances in the production of ultra-cold atomic gases have opened a new field of research at the interface of atomic physics and condensed matter physics. The goal of this project was to study theoretically and experimentally how two-dimensional gases of ultra-cold neutral atoms can be used to simulate orbital magnetism phenomena that occur for the electron fluids in conducting materials.
Asthma and beta2-adrenergic receptor – Asthmatreat
If antagonists of the ß2 adrenergic receptor reduce antigen-induced airway inflammation in mice, the cell types that are the target of these antagonists remain to be identified as well as their mechanisms of action.