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Disease Ecology in a modified world: Linking combined environmental stressors, population dynamics and movement ecology to understand the circulation of infectious agents – EcoDIS
Environmental stresses - such as pathogens or pollution - can alter wildlife survival and reproduction. These changes can in turn affect the movements of these animals, influencing the spread of the pathogens they harbour. EcoDIS examines these links in an anthropophilic seabird, the Yellow-legged Gull.
Mental health disorders and pandemic context: a multidisciplinary approach of psychological response trajectories and factors of resilience in university students – REUNI
of cancer and cardiovascular diseases. The Hauts-de-France (HdF) region, particularly marked by these [...] for decision-makers in their way of managing this type of crisis.
m6A RNA methylation: a new pathway controlling endogenous retroviruses – MARMER
of spontaneous pathological mutations result from de novo ERV insertions, half of which originate from [...] these control mechanisms are not active in all cell types or developmental periods, suggesting that other
ATP P2X4 receptor in ALS pathogenesis and biomarker – P2XforALS
upregulated by mobilization of intracellular pools and/or de novo expression in glia or neurons. We have recently [...] peripheral macrophages in SOD1 mice compared to wild-type animals at pre- and symptomatic phases. Hypotheses-
Ecodesign of fruit and vegetable postharvest chain: Optimization of packaging and cold chain – EcoFreshChain
The main reasons postharvest fruit and vegetable loss are the non-optimal ambient temperature and humidity, inappropriate packaging, logistic organization and consumer behavior. The plastic packaging for sale of fresh unprocessed fruits and vegetables is prohibited since 1/1/2022, exceptionally until 2026 for products of high spoilage such as strawberries.
CrossOver interference phenomenon: regulating crossover number and spatial PATTerning during meiosis – CO-PATT
CrossOver interference phenomenon: regulating crossover number and spatial PATTerning during meiosis
MICROTUBULE INNER PROTEINS (MIPS): from molecular identification to structural properties and functions – MIP-MAP
Following the discovery of the presence of MAP6 inside neuronal microtubules, MIP-MAP aims to determine whether other members of the MAP6 family are also MIPs as well as their roles in the physiology of cilia and flagella, structures in which they are highly expressed. Regarding MAP6, the aim is to determine the ultrastructural basis of its intraluminal localization and to detect microtubules containing MAP6 inside neurons.
Natural Breaking WavEs and Sediment Transport during beach recovery – WEST
WEST project focuses on Wave Boundary Layer and sediment transport at the land-sea interface, specifically on sandy beaches. It relies on the combination of observations and modeling approaches to understand the variability of the coastal environment and aims to fill the gap between theory and in situ measurements of nearshore dynamics.
HYpoxia and alternatively activated MAcrophaGEs as novel molecular imaging targets for early monitoring of therapy efficacy in Idiopathic Pulmonary Fibrosis – HYMAGE-IPF
Idiopathic pulmonary fibrosis (IPF) is a progressive disease. Therapeutic options are limited with ninedanib and pirfenidone, which slow down the progression of fibrosis. Pulmonary hypoxia is a clinical feature of IPF patients but its exact role in disease progression remains poorly understood. Pulmonary hypoxic areas are found in IPF patients and promote alternative activation of M2 macrophages expressing CD206. The secreted form of heat shock protein (HSP)-90 and its receptor, LRP1, are involved in M2 polarization under hypoxic conditions.
ET-Nod : Effectors Triggering Nodulation In legumes – ET-Nod
Legumes play a major agronomical and ecological role due to their ability to fix atmospheric nitrogen during symbiosis with rhizobia. In the Frame of the SymEffectors ANR project (2016-2020), we revealed an alternative symbiotic process that does not rely on the Nod factor synthesis by the rhizobia but by secretion of effectors translocated by the T3SS machinery. Among the effectors required for symbiosis, we identified the nuclear-targeted ErnA effector as a key actor for nodule organogenesis.