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Automatic redistribution of a fleet of car-sharing vehicles and parking valet – VALET
Objective: Realization of an automatic redistribution system for shared vehicles; And Parking Valet Target markets: Car sharing operators, rental cars, automatic taxis; Parking and recharging center operators, shopping malls, etc. Technical / regulatory background: technical maturity but classic regulatory issue related to the driverless vehicle Trend: current and current topics, needs and demands identified, important market in sight.
The roles of NKp46 in Innate Lymphoid cells – NKp46+-ILCs
Several key elements of NK cell target recognition and NK cell function remain to be unveiled. In particular, the cellular ligand(s) for NKp46, the major NK cell specific activating receptor highly conserved across mammals and expressed by all mature NK cells, is/are still missing. <br />We will investigate:<br />Specific aim#1: What is/are the ligand(s) of NKp46?<br />Specific aim#2: What is the function of NKp46?
Cytoskeleton remodeling by storage endosomes – molecular mechanisms and impact on the immune response – CytoEndoStor
Slow recycling storage endosomes (SRSE) are a particular endosomal population that is described by the aminopeptidase IRAP, a protein with dual function.
CaFeO2.5 analogous Brownmillerites prospecting substitution of ceria-based materials for heterogeneous Catalysis – CaFeCAT
The objective of the ANR project CaFeCAT is to study oxygen-deficient perovskites, in particular Brownmillerite type oxides, as active catalyst supports. Within the project, we want to focus in the first place at CaFeO2.5 (a stable line phase) and SrFeO2.5 (known to have great flexibility in the oxygen content) as catalyst support. The correlation between defect structure, oxygen mobility and possibly catalyst performance represents one of the main objectives.
Impacts of global change on dispersal costs – DISPCOST
Impacts of global change on dispersal costs: roe deer as a model
Tanycytes shuttle leptin into the metabolic brain: mechanistic insights and role in the pathophysiology of hormonal resistance and diabesity – GlioShuttles4Metabolism
During previous work supported by the ANR (GLIODIABESITY, 2009-2013), we raised the groundbreaking notion that tanycytes, a specific type of hypothalamic glial cells, act as “gatekeepers” that regulate the access of blood-borne signals to the hypothalamus (Langlet et al., Cell Metab 2013), and in particular, its vesicular transport into the cerebrospinal fluid, from where it enters other leptin-sensitive regions (Balland et al., Cell Metab 2014).
Multiscale sequencing of G/C rich repeated genomic DNA via single molecule manipulation in magnetic tweezers – Museq
few sequencing techniques which does not rely on de novo nucleotide incorporation is sequencing by o [...] tandem-repeated DNA molecules with high G/C content, a type of sequence challenging for most sequencing techniques [...] tools. The goal is to extend the technology towards de novo sequencing, in particular handling secondary
Dynamics of Nuclear Architecture and LIFEspan – DNA-Life
The 3D organization of the genome is an important control mechanism of genomic function.<br /><br />Our recent data unveiled that chromosomes adopt distinct organizations according to the metabolic status of the cell. In particular, long-lived quiescent cells cells group their telomeres into a hypercluster, reshaping the genome architecture into a conformation that may contribute to maintain longevity of<br />quiescent cells (Guidi et al, 2015).
Deforming Integrable Sigma-models – DefIS
The primary goal of DefIS is to push forward the current frontier of knowledge on integrable field theories. Few field theories have the property of being integrable. Their study has nevertheless proved to be of great importance for theoretical physics. The reason is that integrability allows for the use of specific techniques in order to compute exact results. DefIS aims to construct the full landscape of integrable sigma-models and to determine its characteristics.
Mechanisms and frequency of virus-mediated horizontal transfer of genetic material between animals – TransVir
Les transferts horizontaux (TH) correspondent à la transmission d’ADN entre organismes non nécessairement apparentés, sans reproduction. Si un grand nombre de TH ont été caractérisés chez les eucaryotes, on ne sait toujours pas comment ces transferts se produisent. Ce projet vise à tester l’hypothèse selon laquelle les virus pourraient être des vecteurs efficaces de TH entre animaux.