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ADAR1 and RNA editing in development and maintenance of peripheral nervous system – RNAediting-inPNS
ADAR1 and RNA editing in development and maintenance of peripheral nervous system
Adipose tissue-derived progenitors are essential protagonists of Skeletal Muscle Regeneration – ARMURE
realistic project based on a combination of in vitro and ex vivo experiments lying on both mastered and cutting [...] muscle stem cell function in vitro as a prelude start to functional in vivo approaches and then the c [...] different animal models. With these integrated in vivo approaches we expect to show that the transient
All-in-one 3D cell-based hollow liver capsules for drug screening assays: a comprehensive engineering, functional and molecular investigation – REVIL
robust protocols to recapitulate in vitro the proliferative in vivo capability of PHHs encountered during [...] need for the design and development of reliable vitro human hepatic models that may be eligible for the [...] the environmental cues received by hepatocytes in vivo, including the physical interactions between PHHs
Allergy to COVID-19 Vaccines – ALLCOV
skin testing and ex vivo restimulations. Lastly, we will develop innovative in vitro diagnostic tests to
An injectable antibacterial hydrogel to promote human dental pulp regeneration – ENDONANOBIOTIC
nanocomposite hydrogel on an endodontic biofilm in vitro, its influence on DP-mesenchymal stem cell behaviour [...] regenerative potential in infected mouse teeth in vivo, and murine immune responses. This project is planned
Analysis of Genotype-phenotype correlation in Intellectual Disability for improving diagnosis and proposing personalized medicine: PAK3 example – IDGePhe-PAK
with the patient’s clinical traits. Our ex-vivo and in-vitro preliminary analyses allowed us to propose
At the origins of anemia and thrombocytopenia in Fanconi anemia. – FANCDIFF
hematopoietic cells from Fanca+/+ and Fanca-/- mice in vivo (WP1). 2- characterize the nucleolar, ribosome [...] and Fanca-/- murine primary cells or cell line in vitro (WP2). 3- characterize the nucleolar and ribosome
Bioinspired interface engineering of DGL-based hydrogel with high mechanical performance and bioactive properties for in vitro biomaterial platform – DENDRICELLPLATFORM
several protocols inducing ex vivo stem cell differentiation before in vivo transplantation. But to obtain [...] tissues or organoids, a main drawback is the ex vivo production of clinically relevant quantities of [...] culturing adherent cells which best reproduce in vivo conditions. Natural or synthetic polymers have long
Biomimetic peptide tools to crosslink collagen biomaterials and to target a specific collagen-binding integrin for cartilage tissue engineering – CARTEGRIN
adhesion of chondrogenic MSCs in biomaterials in vitro, as well as favor their differentiation into ch [...] stabilization and ability to integrate cartilage in vivo. THP-functionalized collagen biomaterials that [...] chondrocytes will constitute, on the one hand, an in vitro platform to model cartilage ; and on the other hand
Blood-brain barrier crossing of conventional and new antidotes to treat organophosphate poisoning. – BHE-OP-Antidotes
University de Bordeaux) (mouse model, in vitro and in vivo studies of BBB and its permeability). [...] project uses two complementary and validated in vivo models for this type of work, the zebrafish larva