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3D integrated multifunctional MRI sensors based on Molded Interconnect Device technology in tissue engineering regenerative medicine – ESTIMATE
In the last decades, the progress in the field of tissue engineering for regenerative medicine (TERM) has been tremendous. However, there is still no effective 3D method to evaluate non-invasively in vitro and in vivo engineered tissues. Therefore, the main objective of ESTIMATE is to democratize multiparametric MRI for the characterization of engineered tissues from the synthesis to the implantation stage.
A MULTIdisciplinary approach to decipher the first step of aroma MIXture perception. – MULTIMIX
Odors that we detect in our environment result from the perception of mixtures of odorants. Several of these mixtures can lead to a homogeneous percept: odor blending or masking by one component.<br />MULTIMIX aims to identify the biological, molecular and sensory characteristics of odorants that contribute to a homogeneous percept. It will provide keys for the improvement of the flavoring of foods formulated according to nutritional recommendations.
A novel multi-stage acting antimalarial drug-candidate – plasmodrug
. This original molecule displays excellent in vitro activities even on the artemisinin-resistant parasites [...] solubility, which limit gamhepathiopine activity in vivo. In this context, we thus propose to pharma [...] pharmacokinetic properties and to potentiate its in vivo activity. To this aim, the metabolic stability issue
Axonal transport and neuronal maturation: consequences for synaptic function and neuronal connections in health and Huntington’s disease. – AXYON
connectivity in vivo using a combination of genetic and in utero manipulations in mouse, and in vivo imaging [...] and dendritic transport in health and disease in vitro. While HTT-regulated transport may contribute to [...] t of synapses. We will use state of the art in vitro microfluidic devices recapitulating physiological
B cell signaling and Early Plasma Cell Fate Decision – CascadingPCdiff
Terminal B cell differentiation into Plasma Cell is a highly controlled process to regulate humoral response and failure to complete this cell fate transition predisposes towards immunodeficiency, lymphoproliferation and lymphoma development. Further understanding of the mechanisms by which external inputs regulate cell fate decision is of importance for therapeutic purposes and beyond this, learning to control activated B cells would almost certainly enhances development of vaccines.
Bacterial Sister Chromosome Cohesion – BaCh
During cell proliferation, replication, chromosome segregation and cell division must be coordinated to ensure the stable inheritance of the genetic material. In bacteria as replication progresses, newly replicated loci migrate towards opposite cell halves. Pioneer microscopy observations showed that there is a lag of a few minutes between the time of replication and the segregation of copies. we will refer to this phenomenon as bacterial Sister Chromatid Cohesion (bSCC).
Bicolor imaging with x-Rays to Evaluate A Repair Kit THRroUgh dedicated labelling of stem cells and hydrogel – BREAKTHRU
should be defined not only in-vitro but also and mostly in well-designed in-vivo studies. Therefore, there [...] imaging”, allowing the distinct and simultaneous in-vivo monitoring of stem cells on the one hand and ce [...] SPCCT in the world that was fast enough to allow in-vivo imaging, developed by Philips, was installed in
Cell reprogramming by a novel PAX5 mutant: To B-cells or not to B-cells? – Bcell-ID
high-throughput screening, functional in vitro and in vivo experiments, the present fundamental project [...] features of the human disease. Therefore, this in vivo model gives us the opportunity to address the d
Coeliac disease: mechanisms of resistance to gluten-free diet – COELAR
effect of JAK1 inhibitor(s) will be compared on in vitro growth and survival of RCDII cells and normal T [...] agent to kill RCDII cells will be assessed in ex vivo isolated intestinal cells. Overall, our results
Contribution of Type VI Secretion System Effectors in Adherent Invasive Escherichia coli pathogenicity – EffAIECTS
The Type VI secretion system (T6SS) is a bacterial macromolecular machine involved in interbacterial competition and virulence. A sheath-like structure propels a tube topped by a puncturing spike toward target cells. Toxic effectors interacting with the spike are delivered in bacteria and/or eukaryotic cells. Adherent-Invasive Escherichia coli (AIEC) are pathogenic E. coli strains frequently isolated from patients with ileal Crohn’s disease.