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Development of a lanthanide-based luminescent nanoparticule for the dynamic quantification of autophagy in vitro and in vivo. – Lumiphage
e informations on the autophagic flux in vitro and in vivo non-invasively. The autophagic flux is described [...] to image and quantify non-invasively autophagy in vivo will have an important impact on therapeutic efficiency [...] developped to study the functions of autophagy in vitro, molecules that can be exploited to evaluate dynamically
Development of an ultrasonic device for the estimation of implant osseointegration – OsseoWave
The aim is to obtain the final version of a medical device dedicated to the estimation of the stability of dental implant, which is market ready in order to achieve the promotion of the project.<br />
Dissecting striatal functions of Foxp1 and Foxp2 in social behavior and habit formation – FOXNET
Dissecting striatal functions of Foxp1 and Foxp2 in social behavior and habit formation
Francisella-induced eicosanoid production in the lung: Connection with the inflammasome and consequences on the innate immune responses. – FRANNOÏD
tularensis is emerging as a key model to study in vitro and in vivo in a physiological manner the AIM2-containing [...] inflammasome. In a second time, we will characterize in vivo i) the cellular source responsible for this eicosanoid
Gla-domainless Factor Xa as a new treatment of hemorrhages – MINITEN
Hemophilia is caused by a deficiency in factor VIII or IX. It is treated by the infusions of substitution products that cause the appearence of inhibitory antibodies in up to 30% of the cases. This limitation gave an oppportunity to developp alternative therapies.<br />Direct oral anticoagulants (DOA) target factor X and are used without antidotes. This creates threatened situations particularly in case of trauma-induced bleeds.
Global network for the development and maintenance of nutrition-related strategies for mitigation of methane and nitrous oxide emissions from ruminant livestock – GLOBAL NETWORK
for conducting and assessing data from in vitro and in vivo studies designed to evaluate nutritional
Heat nano-sources for therapeutics – Nan'Onsen
Photo-induced targeting of tumor cells in vitro and in vivo by nano-hybrids and optimization of a sequenced
Hypersecretion in severe airway diseases: an integrated biophysical approach of the Mucociliary aspect of the bronchial epithelium. – mucocil
abnormalities of bronchial epithelium using an ex vivo fully reconstituted epithelium (air liquid interface [...] d epithelium and its mucocilliary component in vitro and its response to an allergen (HDM: house dust
Identification of new causative genes in spinocerebellar degenerations by combination of whole genome scan, next-generation sequencing and biological validation in vitro and in vivo – SPATAX-QUEST
the most promising variants in vitro (Partner 1, cell models) and in vivo by modeling and rescue experiments [...] explore their dynamics of interaction in vitro (Partner 1) and in vivo using C. elegans (Partner 4). A systematic
Immune networks triggered by cytokine thymic stromal lymphopoietin (TSLP) in the pathogenesis of atopic dermatitis – TSLPNetwork
Li, IGBMC, Strasbourg); 2) in vitro human cell co-culture and ex vivo human skin explant culture systems [...] combining the expertise from three partners: 1) in vivo mechanistic studies using powerful mouse genetic