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An Integrated Structural Biology Approach to the study of oncogenic deltaNp73-alpha stabilization induced by the IKK-beta kinase – IKKp73
The IKKß kinase phosphorylates the oncogenic deltaNp73alpha isoform (a member of the p53 tumor suppressor family and named Dp73 from here on) at Ser422. This phosphorylation event promotes the formation of a tight complex between IKKß and Dp73, which associates to the promoters of p53-regulated genes leading to silencing of gene expression. The project aims at characterizing the IKKß/Dp73 complex using an integrated Structural Biology approach.
Biological functionalisation of silicon substituted hydroxyapatite porous ceramics for bone tissue engineering – Céram-Os
He Céram-Os project relates to bone tissue engineering. It aims to develop a new generation of functionalized osteoinductive calcium phosphate bioceramic scaffolds able to maintain tissue volume and shape, control osteogenesis, guide and activate bone ingrowth and promote the vascular integration. Such ceramic scaffolds will provide an adapted surgical solution for the filling and repair of large bone defects as an alternative to cancellous bone autograft or metal implants.
Biosafety of mesoporous silica nanoparticles according to their surface coverage and establishing standards for evaluation – BioSiPharm
This project is in the context of nanoparticles for therapeutic and diagnostics. Recent studies show a growing interest towards silica mesoporous nanoparticles for therapeutic application and / or diagnosis. However there are very few studies about their potential toxicity. This area requires new methods that can be used to connect standard surface characteristics and toxicity.
Cell/extracellular matrix interactions: application to skin repair – SKINHEALING
Use a short sequence of an extracellular matrix protein named laminin involved in cell adhesion and migration, to favour the epithelialisation phase during cutaneous wound repair.
Chaperone-mediated control of toxin-antitoxin systems in Mycobacterium tuberculosis. – mycoTAC
Chaperone-mediated control of toxin-antitoxin systems in Mycobacterium tuberculosis.
Clinical and Immunological Characterization of Lassa Virus Infection in Humans, a Model of Haemorrhagic Fever Syndrome. – Immono-Lassa
the pathogenesis of LASF is based primarily on in vitro experiments and animal models. The observation [...] in individuals infected with LASV. Etending in vivo investigations of the immune parameters associated
DEAD-box RNA helicases: in vivo roles, protein partners, RNA substrates and mechanistic details – HeliDEAD
RNA helicases are ubiquitous proteins found in all three kingdoms of life. They are NTP-dependent RNA binding proteins and RNA-dependent NTPases that are associated with all cellular processes involving RNA. Yeast has 45 different RNA helicases that are generally essential and rarely interchangeable, and they are functionally conserved throughout the eukaryotes. Our laboratory is interested in understanding how RNA helicases work, what are their cellular roles and how they are regulated.
Deregulation of hematopoiesis by Interleukin-10 over-expression: implications for the development of hematological disorders – MYELOTEN
therapy. Such comprehensive approach, from in vivo and in vitro hematopoietic systems to genetic association [...] and use the pMT-10 mice, in combination with in vitro approaches, to unravel, at the cellular and molecular
Design and synthesis of antibody mimics – Mimobody
(1) the selection of CDR-fragments, (2) the assembling of selected CDRs on the cyclopeptide scaffold, (3) the in vitro screening and characterization of good candidates, (4) the grafting of NIR probes and cytotoxic triggering molecules for in vivo experiments.
Determining factors of thea difference in toxicity in intestine and liver for two similar sized nanoparticles used in food and packaging: In vitro and in vivo investigation on uptake and mechanisms involved – SolNanoTOX
MNMs following oral exposure in vivo. Nevertheless, results from in vivo experiments are the main data [...] mechanisms, the project combines integrative in vitro and in vivo approaches to compare the fate, cytogenotoxic [...] investigated in vivo after short-term oral treatment of rodents and compared to in vitro data obtained