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Craniosynostosis and FGF signaling: fishing in murky waters – STARFISH
zebrafish models of MS and XLH and we will perform in vivo vitro analysis using primary cultures of osteoblasts [...] the efficacy of new drugs in vitro (osteoblasts from patients) and in vivo (MS and XLH disease zebrafish)
Spatial regulation of RhoGTPase during cell division through 2 RhoGEF isoforms – Pebbles
analysis. Specifically, in vitro binding assays and GEF assays, combined with in vivo genetic interaction [...] activity. In parallel, in vitro lipid binding assays combined with in vivo examination of Pbl-A and B
Neural Activity induced by ultrasound: from mechano-electric transduction to brain stimulation prosthesis – NeurActiv
complexity, thus efficiently transitioning from in vitro to in vivo studies. We will address the spatio-temporal [...] cortical or deep regions of the brain of several in vivo animal models using low frequency transcranial FUS [...] result of longer wavelengths, studies have shown in vitro that much higher ultrasound frequencies (40 MHz)
SPAtio-temporal control of CEllular differentiation for CARtilage Tissue engineering – Spacecart
chondrogenic differentiation of BM-MSC in vitro and in vivo, and the production of neo-cartilage tissue [...] ation of Runx2 in BM-MSC and its outcome on in vitro chondrogenesis and hypertrophy inhibition and 3) [...] 3) the study of neocartilage production in vivo in the absence of ossification in the long-term. Our
Mechanism of TBP delivery to gene promoters by the SAGA co-activator – SAGA-TBP
variety of promoters by in vitro EMSA, FRET and FCCS methods and in vivo time-resolved crosslinking ChIP [...] Tra1 subunit is considered as a major in vitro and in vivo target for activator binding. However, neither
Controlable RNA expressing Scaffold for Bone Regeneration – CreaBone
differentiation of osteoprogenitors in vitro and ectopic bone induction in vivo 2) Optimize the combination of [...] controlled diffusion and MSC transfection in vitro and in vivo 3) Validate the potential of CreaBone to
Key role of methionine-rich domains in copper homeostasis systems: focus on CueOs – MetCop
copper binding properties, iii) in vitro enzymatic activity and iv) in vivo copper resistance. The multiscale [...] recognised to be involved in copper resistance in vivo, presents a Met-rich domain proposed to be involved [...] domain structural features will be correlated to in vivo copper resistance. MetCop thus ambitions to precisely
Muscle, Adipose and Pancreatic Islet Crosstalk in the Pathogenesis of Type 2 Diabetes – MYODIAB
muscle and pancreatic islets in vitro using cell-based assays and in vivo in mouse models, 3) validate the
Exploiting autophagy-lysosomal dysfunction of immune cells as therapeutic target in periodontal diseases – TopGum
autophagy, on the periodontal inflammation in vitro and in vivo.This project will contribute to a better
iota Carbonic Anhydrase: A key response to CO2 in diatoms – OCEANIA
within 3 workpackages combining a range of in vitro and in vivo methods. The aim of workpackage 1 is to unravel