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GAG mimics for shifting brain function – HomeoGAG
GAG mimics show significant Otx2 binding and in vivo activity, thus providing strong proof-of-concept [...] specificity to Otx2 will first be evaluated in vitro by screening methods that couple online thermodynamic [...] GAG-dependent signaling proteins; subsequent in vivo experiments will impact our understanding of CP
Cell reprogramming by a novel PAX5 mutant: To B-cells or not to B-cells? – Bcell-ID
high-throughput screening, functional in vitro and in vivo experiments, the present fundamental project [...] features of the human disease. Therefore, this in vivo model gives us the opportunity to address the d
Lymphocyte T helper (Th) cell differentiation in patients with inborn errors of immunity to Mycobacterium and/or Candida species – LTh-MSMD-CMCD
ZNF341) causing genes. Specific aim 2: To study ex vivo memory Th (Th1, Th2, Th1*, Th17) subsets in novel [...] cell subsets, especially, Th1, Th1* and Th17 ex vivo in patients with mutations in the recently identified [...] CD4+ T cells (Th1, Th2, Th1* and Th17) induced in vivo by Mycobacteria and Candida antigens in patients
FROM DYNAMICS & STRUCTURAL DIVERSITY OF T6SS MEMBRANE COMPLEXES TO THE DEVELOPMENT OF VIRULENCE BLOCKERS – T6MeD-OC
The WHO has recently published a list of bacterial pathogens representing a growing threat to human health. The therapeutic options to handle this hospital outbreak are becoming sparse due to the antibiotic multi-resistance of these pathogens. New therapeutic options are urgently needed. A new strategy has emerged recently: targeting virulence mechanisms to disarm pathogens and block infection. This strategy required in-depth structural and molecular understanding of virulence nanomachines.
Valorisation of saffron and its floral by-products as sustainable innovative sources for the development of high added-value food products – SAFFROMFOOD
and their cardiometabolic prospects “in vitro” and “in vivo”. -To test the effect of the bioactive extracts
Milk quality all along the dairy chain for a sustainable MILK – MILKQUA
rely on up-to-date system biology (both in vitro and in vivo assays) and OMICs methodologies. Synergy
Deciphering the influence of biomechanics and mechanotransduction during cardiac regeneration in normal and pathological contexts – Forcinregeneration
control pathway activation and morphogenesis in vivo because the mechanical stimuli experienced by EdCs [...] are too complex to be faithfully reproduced in vitro. This timely proposal aims to uncover the cellular
Understanding the dynamic of the vascular niche in pulmonary hypertension (PH). Matrix reprogramming forces PH. – MatriPHate
We propose to functionally manipulate in vitro and in vivo vascular cell-matrix interactions in PH. Based
Elucidate the role played by Rab4b-depenant endocytosis in hepatocyte glucose metabolism regulation – Rab4LiverMetabolism
on the regulation of glucose metabolism in vitro and in vivo. For this I will 1) determine whether Rab
TargEting TREM-1 Receptor in Abdominal Aortic Aneurym – TETRAAA
expression/activity in the context of AAA, in vitro and in vivo, using both peptide inhibitor and genetically