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Evaluation of the anti-CD115 mAb ELB041 to prevent lung fibrosis – MACROFIBRO
experiments will first be performed in vitro and in vivo. In vitro, we will analyze whether ELB041 may regulate [...] (cytokines, myeloid cell populations) modulated by in vivo CSF-1 treatment, (ii) study the effects of ELB041
Role Of bronchial Smooth muscle on Asthma Exacerbations – ROSAE
proliferation of asthmatic BSM cells both in vitro and in vivo. Moreover, I showed that asthmatic BSM cells [...] have an increased mitochondrial mass both in vitro and ex vivo, which is the cause, and not the consequence
Origin and function of the pituitary generator of GH pulses – GH-Gen
The project addresses a critical function in humans and all vertebrates: how are build-up the pulsatile secretion of GH that regulates body growth and metabolism? Our working hypothesis is that the functional network organisation of pituitary GH-secreting somatotrophs decodes fast hypothalamic GHRH inputs in order to transmit this information as slowly-evolving waves of calcium oscillations which leads to circhoral GH pulses into the bloodstream
Novel Therapeutics for Toxoplasmosis and Malaria Directed to New Parasite Targets – NovoTargetParasite
AN3661, has not only potent in vitro activity but also excellent in vivo efficacy to save mice of toxoplasmosis
Inhibition of coronaviruses infections using innovative nanostructures – NanoMERS
The main goal of the NanoMERS project is the identification of specific and efficient nanomaterials derived anti-MERS-CoV agents effectively inhibiting viral entry and their in vitro and in vivo testing. The focusis on the use of carbon based nanostructures, notably modified C-dots and graphene-dots and nanoparticle formulations of poly(D, L-lactide-co-glycolide) (PLGA).
Control of actin on endosomes and ciliogenesis by the Rab35 GTPase and two novel effectors: An integrated view. – RabEndoCilio
Control of actin on endosomes and ciliogenesis by the Rab35 GTPase and two novel effectors: An integrated view.
Bicolor imaging with x-Rays to Evaluate A Repair Kit THRroUgh dedicated labelling of stem cells and hydrogel – BREAKTHRU
should be defined not only in-vitro but also and mostly in well-designed in-vivo studies. Therefore, there [...] imaging”, allowing the distinct and simultaneous in-vivo monitoring of stem cells on the one hand and ce [...] SPCCT in the world that was fast enough to allow in-vivo imaging, developed by Philips, was installed in
Evolution and dynamics of dissemination of Tolerance towards AntiBiotics in biofilms (EvoTolAB) – EvoTolAB
Bacterial infections are a leading cause of morbidity and mortality. The increasing resistance to antibiotics among pathogenic bacteria is a major health concern. These infections are often chronic and due to the presence of biofilms developing on medical devices or mucosa that can tolerate high antibiotic concentration. The potential link between this biofilm tolerance and emergence of resistance is unknown. This is the rationale of this project.
Identification of the mechanobiological factors involved in platelet formation – PlatForMechanics
Platelets play vital roles by ensuring hemostasis. Today, the mechanisms of platelet formation are still insufficiently understood as exemplified by poor yield of in vitro platelet production. Here, we have proposed an integrative approach to study the role of mechanobiological factors in the biogenesis of platelets. Our aim is to identify how the 3D confinement and the stiffness of BM provide key intracellular signals for MK to fully mature and trigger the platelet release.
Hydrogel-based stretchable device with tissue electrical sensing or stimulation ability – STRETCH
investigated in vitro and the best candidates will be selected to assess their performance in vivo in a cortical [...] promising for electrical stimulation and recording in vivo, because of their mechanically permissive structures