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Francisella-induced eicosanoid production in the lung: Connection with the inflammasome and consequences on the innate immune responses. – FRANNOÏD
tularensis is emerging as a key model to study in vitro and in vivo in a physiological manner the AIM2-containing [...] inflammasome. In a second time, we will characterize in vivo i) the cellular source responsible for this eicosanoid
The adhesion-GPCR BAI3 and its signaling pathway in schizophrenia: from mice models to patients. – CERBAIS
cal level, at the physiological level in vitro and in vivo, and at the level of behavior using a neu [...] the BAI3 receptor in neurons in vivo, and use a knockdown approach in vivo to validate the role of these
Deregulation of hematopoiesis by Interleukin-10 over-expression: implications for the development of hematological disorders – MYELOTEN
therapy. Such comprehensive approach, from in vivo and in vitro hematopoietic systems to genetic association [...] and use the pMT-10 mice, in combination with in vitro approaches, to unravel, at the cellular and molecular
Magneto-Chemotherapy: Modeling of Radiofrequency Magnetic Field-Induced Delivery of an Anticancer Drug by Polymer Nano-Vesicles and Monitoring by MRI of a Glioblastoma Model – MagnetoChemoBlast
biological with both in vitro (cytotoxicity and uptake pathways ito cells) and in vivo (subcutaneous tumor [...] efficient entrapment and controlled release of drugs in vitro, evaluating the carrier biodistribution after injection
Involvement of microRNAs in the response to SRI antidepressants – miR-Dep
Serotonin Reuptake Inhibitors (SRIs)-type antidepressants, among which Prozac is the most known, are used from the 80's to treat depressive states. The molecular basis of the beneficial effect afforded by SRIs consumption as well as mechanisms of resistance to SRIs are still enigmatic. The aim is to identify such mechanisms to improve therapeutic approaches to combat depression.
Migration of CD8 T cells into the central nervous system – T cell Mig
To achieve this goal we propose to investigate in vivo CD8 T cell migration into the CNS, using robust [...] analysis of CD8 T cell transmigration using in vitro models of blood-brain barrier will be performed [...] therapeutic blockade of CD8 T cell migration in vivo. Finally, neurobiologists in Paris (Dr. Isabelle
The cellular trafficking of Fe-S clusters in plants – Fe-S traffic
This work focuses on the proteins of the ISCA and NFU families of Arabidopsis thaliana involved in the late stages of Fe-S cluster transfer towards chloroplast and mitochondrial proteins.
Polymeric nanovectors transfer, from blood flow to tumors – Polytransflow
In the domain of drug delivery, the influence of margination (migration of objects from vessel center to walls) on the transfer of vectors from blood stream to tumor tissue is a poorly studied step. One reason is that along the journey between injection and delivery sites, many processes arise, which are related to mechanics and physics, chemistry and biology. This project aims at focusing on the steps enabling vectors such as polymersomes, to leave the bloodstream to get to the tumor site.
Uncovering the role of novel histone modifications in transcription and their mechanistic impact on chromatin function – CoreAc
The aim of this project is to decipher the role of histone modifications situated on the lateral surface of the histone octamer. This location of these modifications is particularly important since it can directly affect the interaction of the histone proteins with the DNA and thereby directly affect chromatin dependent processes.
Heat nano-sources for therapeutics – Nan'Onsen
Photo-induced targeting of tumor cells in vitro and in vivo by nano-hybrids and optimization of a sequenced