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Design and synthesis of antibody mimics – Mimobody
(1) the selection of CDR-fragments, (2) the assembling of selected CDRs on the cyclopeptide scaffold, (3) the in vitro screening and characterization of good candidates, (4) the grafting of NIR probes and cytotoxic triggering molecules for in vivo experiments.
Synergistic and toxic cocktail effects of low dose endocrine disruptors – TOXSYN
structural tests and novel cell-based in vitro and in vivo, embryo-based assays for studying effects [...] of mono (2-ethylhexyl) phthalate (MEHP), • in vitro tests that show synergistic activation effects of [...] (high-throughput mammalian and non-mammalian in vitro assays) and whole organism levels (embryo-based
Role of Cyp46 in cholesterol metabolism and neuroprotection in Huntington’s Disease – CYPHunt
pathology. ShRNAs approaches will be used in vitro and in vivo for this purpose. Altogether, this project [...] restoring CYP46A1 expression in striatal neurons in vitro significantly reduces neuronal dysfunctions induced [...] motor behavior performance in the R6/2 HD mice in vivo. Therefore, our aims are to propose a new therapy
Multifunctional Nanosensors for probing intracellular protein kinase cancer biomarkers – NANOMULTISENS
simultaneously, which can be applied both ex vivo and in vivo, through functionalization of carbon nanotubes [...] their kinase activity, which have been validated in vitro using recombinant proteins and cell extracts and [...] different kinase activities will be validated in vitro with recombinant kinases and cell extracts. These
Mechanisms of stem and progenitor cell regulation in mammary gland – MamStemCell
phenotype and regenerating potential using in vitro and in vivo approaches. - To define the molecular ch [...] integrin signalling intermediates and perform in vitro and in vivo stem cell assays (two- and three-dimensional [...] approach to follow the progeny of these cells in vivo at different developmental stages. - To identify
Post-traumatic brain and epilepsy – Traumep
The temporal lobe epilepsy is one of the most common types of epilepsy in adults and is often drug-resistant. This type of epilepsy is associated with reorganization of the neural network in the hippocampus. The aim of the project is to elucidate the cellular mechanisms involved in the reorganization of the neural network to better understand epileptogenesis.
Molecular mechanisms controling IL-1ß-induced Th9 cell anticancer functions – MMTAF
effector cells in vivo. These aims will be addressed by combining in vitro and in vivo approaches such
Role of phosphatidylinositol 5-phosphate on the concerted membrane and actin remodeling, cellular architecture and trafficking. – PI5PACTION
PtdIns5P, we will use a combination of in vitro and in vivo original multidisciplinary approaches including [...] e analysis of intracellular organization and in vivo membrane and actin cytoskeleton dynamics studies
Responsive Probes for the quantitative detection of Zn(II) and Cu(II) by MRI and PET/SPECT – ZiCoRes
Responsive Probes for the quantitative detection of Zn(II) and Cu(II) by MRI and PET/SPECT
Dissecting striatal functions of Foxp1 and Foxp2 in social behavior and habit formation – FOXNET
Dissecting striatal functions of Foxp1 and Foxp2 in social behavior and habit formation