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Plasma and Carbon Monoxide, good Allies for Medical Applications – MediCO-Plasma
by studying the plasma treatment in vitro on skin cells and in vivo on wounded mice. The outcome of M
Endothelial damage and repair in SARS-CoV-2 related vascular injury – ENDOCOV-19
intravital imaging techniques, and the in vivo and in vitro testing of the endothelial function. Extensive [...] mouse models and human samples as well as in vivo and in vitro investigation Aim 3 To describe the status
Development and evaluation of multiphasic, biomimetic substitutes of the dura mater – DuraLayer
objective is here to develop, thanks to an extensive in vitro cell characterization step, specific phases promoting [...] differentiation and functionality (WP3). Such an in vitro exhaustive cellular analysis will not only highlight [...] but will also strengthen our knowledge of the in vitro behaviour of dural cells, still limited nowadays
Modulation of myofibers integrity and function in health and disease – Atrorescue
we will use in vitro cellular assays (cultured myotubes and mature myofibers) and in vivo mouse models [...] control of the ER, SR, T-tubules and ECC, in vitro and in vivo. Thus, ATRORESCUE will improve our understanding [...] as a strategy to rescue CNM related phenotypes in vivo may pave the way to treat other neuromuscular diseases
The microtubule cytoskeleton network in thyroid development and physiology and platelet functions – MITHYPLA
platelet function in already established in vivo and in vitro models.
Phage-Bacteria-Host Tripartite Interactions in Gut Health and Disease – VENTRIS
barrier and its inflammatory state, using in vitro and ex vivo model, including clinical samples; (ii) the
Heterogeneous nanocrystals For Near-infrared BioImaging – NanoFBI
the in vivo study in NanoFBI will be very meticulous and thorough, resting on solid in vitro foundation [...] us detection with respect to excitation. 4) In vivo application with murine cardiology as a main focus
Ontology-based decision support plateform, for evaluating the clinical severity of Covid-19 patients and orienting them towards the right medical care option – ORIENT-COVID
this system first "in vitro" on fictitious cases with a consensus panel, then "in vivo" in the real context
Coordinated targeting of ER-mitochondria contact sites in cells from the gut, pancreas and liver, triumvirate for optimal control of glucose homeostasis – TriMAMvirate
MAMs using an organelle spacer in several in vitro and in vivo models. 3) To validate both in mice and humans [...] preclinical models of obesity and T2D. By combining in vitro approaches, different preclinical models, validation
Interaction between PKA signalling and TRIM28 in ovarian maintenance and pathology – OvaryProtect
Sertoli cells. Indeed, our preliminary in vitro and in vivo results shows that PKA signalling induces [...] background and pathological situations. Using in vitro approaches and an important toolkit of mouse genetics