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Molecular mechanisms of sensitization to allergic asthma and therapeutic innovation – Innovasthma
extract will be evaluated in vitro in the reporter cell lines as well as in vivo on the parameters of the [...] epithelial cells, according to the results obtained in vitro in the first part. To specifically invalidate Nod1
Evolution and function of plant NO-Synthases – ALGAE-NOS
studies, structural characterization, and in vitro/in vivo functional investigations: In silico: we will [...] activity for distinct physiological settings. In vivo: in vivo activity and role of plant NOSs will be investigated [...] critical role in NOS function or structure. In vitro: the structure of the catalytic site of model NOSs
Understanding the dynamic of the vascular niche in pulmonary hypertension (PH). Matrix reprogramming forces PH. – MatriPHate
We propose to functionally manipulate in vitro and in vivo vascular cell-matrix interactions in PH. Based
Elucidate the role played by Rab4b-depenant endocytosis in hepatocyte glucose metabolism regulation – Rab4LiverMetabolism
on the regulation of glucose metabolism in vitro and in vivo. For this I will 1) determine whether Rab
Coeliac disease: mechanisms of resistance to gluten-free diet – COELAR
effect of JAK1 inhibitor(s) will be compared on in vitro growth and survival of RCDII cells and normal T [...] agent to kill RCDII cells will be assessed in ex vivo isolated intestinal cells. Overall, our results
Identification of the mechanobiological factors involved in platelet formation – PlatForMechanics
Platelets play vital roles by ensuring hemostasis. Today, the mechanisms of platelet formation are still insufficiently understood as exemplified by poor yield of in vitro platelet production. Here, we have proposed an integrative approach to study the role of mechanobiological factors in the biogenesis of platelets. Our aim is to identify how the 3D confinement and the stiffness of BM provide key intracellular signals for MK to fully mature and trigger the platelet release.
Neurotoxicity induced by environmental amino acids-mimetic toxins through inflammation – NeuroTEM
Il s’agit d’étudier les effets de faibles doses de polluants de l’environnement dans la période périnatale sur le développement cérébral et la mise en place de neuropathologies à long terme. La synergie entre des évènements inflammatoires pendant la gestation ou chez les nouveau nés et les effets toxiques des polluants est recherché.
Bacterial Sister Chromosome Cohesion – BaCh
During cell proliferation, replication, chromosome segregation and cell division must be coordinated to ensure the stable inheritance of the genetic material. In bacteria as replication progresses, newly replicated loci migrate towards opposite cell halves. Pioneer microscopy observations showed that there is a lag of a few minutes between the time of replication and the segregation of copies. we will refer to this phenomenon as bacterial Sister Chromatid Cohesion (bSCC).
A MULTIdisciplinary approach to decipher the first step of aroma MIXture perception. – MULTIMIX
Odors that we detect in our environment result from the perception of mixtures of odorants. Several of these mixtures can lead to a homogeneous percept: odor blending or masking by one component.<br />MULTIMIX aims to identify the biological, molecular and sensory characteristics of odorants that contribute to a homogeneous percept. It will provide keys for the improvement of the flavoring of foods formulated according to nutritional recommendations.
Nanoparticle lifecycle in human: the key and hazardous role of lysosomal sequestration – CYCLYS
assessed comparatively for the first time in vitro and in vivo to examine potential interference with ly