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Deciphering the influence of biomechanics and mechanotransduction during cardiac regeneration in normal and pathological contexts – Forcinregeneration
control pathway activation and morphogenesis in vivo because the mechanical stimuli experienced by EdCs [...] are too complex to be faithfully reproduced in vitro. This timely proposal aims to uncover the cellular
Presubicular bursting and visual anchoring of the head direction signal – BURST
How the brain encodes spatial orientation depends strongly on vestibular and visual signals, but the cellular and circuit basis for visual anchoring of the internal compass remains unknown.<br />We will focus on the presubiculum, and the feedback to the lateral mammillary nucleus, that seems to rely on intrinsic bursting neurons of layer 4. Our project evolves around the idea that a burst feedback signal has a key role for visual updating of the head direction signal.
Emerging mycotoxins: a new risk for Human and animals? – EmergingMyco
Mycotoxins produced by certain molds contaminate more than 70% of the world's cereals and represent a public health problem. The main toxins of Fusarium are regulated in Europe in food and feed. However, Fusarium produce other mycotoxins that are known as «emerging« mycotoxins because they are poorly characterized or recently identified. This project aims to determine their occurrence in French cereals and their toxicity.
Control of actin on endosomes and ciliogenesis by the Rab35 GTPase and two novel effectors: An integrated view. – RabEndoCilio
Control of actin on endosomes and ciliogenesis by the Rab35 GTPase and two novel effectors: An integrated view.
Role of Type IV pilus retraction in bacterial pathogenesis – RETRACTOPATH
Type IV pili (Tfp) are highly dynamic long filamentous structures that are produced by numerous pathogenic bacteria. They mediate an extraordinary array of functions, including motility, DNA uptake, bacterial aggregation or adherence to host cells. Pilus retraction generates remarkably high force. Such force acts as a mechanical signal to both bacteria and host cells. To date how such force is sensed in host cells and contribute to bacterial pathogenesis has been poorly explored.
Contribution of Type VI Secretion System Effectors in Adherent Invasive Escherichia coli pathogenicity – EffAIECTS
The Type VI secretion system (T6SS) is a bacterial macromolecular machine involved in interbacterial competition and virulence. A sheath-like structure propels a tube topped by a puncturing spike toward target cells. Toxic effectors interacting with the spike are delivered in bacteria and/or eukaryotic cells. Adherent-Invasive Escherichia coli (AIEC) are pathogenic E. coli strains frequently isolated from patients with ileal Crohn’s disease.
Deciphering Legionella pneumophila induced epigenetic modifications: characterization of a prokaryotic histone deacetylase – LEGENhD
characterize its enzymatic activity both in vitro and in vivo, and in particular during infection: LpHDAC [...] effector that directly deacetylates host histones in vivo; (iii) understand the role of LpHDAC in the context
Meningococcal Infections-on-Chip: Integration of the Tissue Architecture – MeningoChip
ied in vitro models (2D monolayers of endothelial cells or Transwell) or on a complex in vivo human skin [...] structure and the function of Nm-target tissues in vitro, in order to investigate the course of meningococcal [...] strategies has permitted the design of advanced in vitro assays such as perfusable 3D microvascular networks
Development of new, efficient and ecofriendly rodenticides to control rodent outbreaks – ROC
efficacy of these new inhibitors by in vitro, ex vivo and in vivo studies. The project relies on the
Dialogue(s) for fertility: deciphering spermatozoa-oviduct interactions and their implications for artificial insemination in dairy cattle – DIALOG
oviductal secretome in vivo; 2) translate the in vivo oviductal milieu into a refined in vitro model to faithfully