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The future for regenerative medecine: transdifferentiation by naturally secreted inducers of cell identity – iTraNS
either ex vivo or in situ. Because of limited sources of donor cells, producing them in vitro from adult [...] demonstrate its universality and to test direct in vivo iTD in mouse models. Our concept iTraNS is expected
The PrPC PDK1 TACE signaling axis at the cross-road of several aggregate-prone protein-associated neurodegenerative diseases – Prpc Pdk1
represents a biomedical challenge. Combining in vitro and in vivo experiments, we provided evidence for de
Integrative analysis of the biology of plasma cells in health and disease – AUTO-PLASMO
Plasma cells are essential for the development of an efficient and long-lasting protection against infections but they are also involved in the development of several autoimmune diseases. <br />This project main objective is to improve our knowledge of plasma cell biology, from their generation in the secondary lymphoid organs to their long-term maintenance in survival niches, and by doing so to identify new ways to target and regulate this cell subset.
Targeted delivery of therapeutic siRNA to Ewing sarcoma junction oncogene by traceable diamond nanocrystal – antibody fragment conjugate – DiamESTar
the therapeutic efficacy will include in vitro and in vivo measurement of EWS-FLI1 inhibition and of
AGuIX® theranostic nanoparticles for vascular-targeted interstitial photodynamic therapy of brain tumors – PhotoBrain
contrast agents. They will be first evaluated in vitro for their ability to produce singlet oxygen (1O2) [...] target NRP-1, and to confer photosensitivity. In vivo experiments will be performed in rats bearing an
Synthetic Biology: Exocytosis – SynBioExo
Exocytosis occurs when a vesicle initially in the cytosol and containing cargos (e.g. enzymes, hormones or neurotransmitters) fuses with the plasma membrane, releasing the cargo into the extracellular space. In this proposal, we plan to create an artificial programmable cellular pathway for controlled release of stored substances i.e. synthetic exocytosis.
Preclinical approaches towards therapeutic intervention for fragile X premutation carriers – Drug_FXSPreMut
multidisciplinary consortium have excellent in vivo and in vitro models of FXTAS, valuable resources and
Fast Skeletal Troponin Activation for Restoring Muscle Strength in Mouse Models of Nemaline Myopathy: a Molecular, Cellular, Metabolic and Functional Assessment – TREAT-NEMMYOP
efficacy, we will combine measurements of in vivo and ex vivo muscle strength, non-invasive magnetic resonance [...] in NM, on (2) new NM biomarkers, and on (3) in vitro effects of troponin activators on muscle fibres
Repurposing biomolecules for the treatment of epidermolysis bullosa – EBThera
human DEB cells in vitro and to attenuate soft tissue fibrosis in DEB mouse models in vivo. The data will
Targeting Alpha-Synuclein for Treating Multiple System Atrophy – ARTEMIS
(in-vitro and in-vivo), astroglial and microglial activation, as well as motor deficits (in-vivo). This [...] a-synuclein accumulation. Using complementary in-vitro and in-vivo models, we will test the efficacy of: 1) [...] oxidative stress, unfolded protein response (in-vitro), cell survival, monomeric, oligomeric and post