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Neuroprotective properties of peptides derived from the Bornavirus X protein – X-protect
effect in vitro, by acting at the mitochondrial level. This protection was also observed in vivo, in a mouse [...] Among these peptides, one appears to display in vitro neuroprotective properties comparable to that seem [...] neuroprotective promise of X-derived peptides in vivo. More specifically, we propose: 1) To test the
Investigating the roles of cilia during mammalian neurogenesis – CiliaStem
Ciliopathies are human pathologies characterized by ciliary deficiency and whose major clinical features include brain defects. We are focusing our efforts to decipher the molecular mechanisms involved in these pathologies by studying mouse genetic models.
Cochlear hair cell endoplasmic reticulum homeostasis and deafness. – COC-ERpathy
based on a particular combination of in vitro and in vivo techniques, will give us the opportunity to
Role of transcription termination in the control of hidden transcription in yeast S. cerevisiae – TermCUT
Role of transcription termination in the control of hidden transcription in yeast S. cerevisiae
Microwave assisted Milligel synthesis under continuous Flow – MIMIFLOW
Novel dosage forms of active species are strongly demanded for drug delivery. Polymer-based drug depots, which degrade in-vivo during a predefined time and dose are a promising strategy and will be investigated in MIMIFLOW. The syntheses will be performed in microwave reactors, with a dedicated focus on millifluidic continuous-flow systems in order to produce polymer networks with defined shapes and geometries for their specific applications.
Use of SUlfated POlysaccharides for the treatment of BEE nosemosis – SUPOBEE
The nosemosis, potentially a lethal disease for the honeybee, is an important factor in the phenomenon of colony collapse of this insect. In the absence of treatment in Europe against this disease, it is necessary to develop new ways of fighting nosemosis to improve the honeybee health.
Structure, function and dynamics of the transcription factor TFIIH – TFIIH-Complexes
ARCH domain of XPD for TFIIH activity in vivo and in vitro. - Live cell imaging techniques will provide [...] association between core-TFIIH, XPD and CAK: (i) In vitro biochemical and biophysical characterization of
Glycomimetics targeting Pseudomonas aeruginosa: Synthesis, screening on a DNA-based carbohydrate microarray and evaluation on bacteria – GLYCOMIME
Pseudomonas aeruginosa is the third bacterium involved in nosocomial diseases and the main cause of death of the patients achieves of the cystic fibrosis. It's characterized by its capacity to develop resistances in antibiotics. This project aims at discovering new molecules targeting not vital functions of the bacterium but its factors of virulence
Impact of translation initiation factor eIF2-a phosphorylation during stress exposure. – STRESSOR
One of the most prominent features of the cellular stress response, is the phosphorylation of the alpha subunit of the eukaryotic translation initiation factor 2 (eIF2-a). This phosphorylation impacts many functional compartments of the cell, in a response known as the integrated stress response (ISR) which influences profoundly gene expression, membrane traffic, autophagy and apoptosis
Development of novel IL-17 antagonists in oncology – OREGA-17
epitope and neutralizes all IL-17 isoforms. In vitro and in vivo Proofs of Concept (PoC) with both types of [...] isoform antagonist antibody (based on results from in vivo PoC) for the treatment of human tumors.