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Controlled cell adhesion and activity onto TAl6V Titanium alloy by grafting of the Surface: elaboration of orthopaedic implants capable of preventing joint prosthesis infection. – ACTISURF
infection and inflmmatory response in vitro and in vivo, clinicians veterinary, orthopedists in charge [...] protheses, surface chemists, biologists of the in vitro cell response, microbiologists specialiezd in infection
Le rôle des ions métalliques dans l'agregation, la production de radicaux et la toxicité du peptide amyloïde-? – Neurometals
It was shown that copper and zinc ions play a key role in the aggregation of A? peptides and neuronal toxicity. The purpose of this project was to understand the role of copper and zinc ions in the two key stages of AD development as well as the molecular mechanisms they are associated
Synthèse de nouveaux nitroxides pour le diagnostic et l'étude de pathologie chez le petit animal via l'activité des protéases vue par IRM et effet Overhauser. – NITROMRI
No non-invasive spectroscopic techniques as efficient as MRI and suitable to monitor the enzymatic activity in tumors are available. This project aims to develop a new technique of MRI: the Overhauser-enhaced MRI which amplifies the conventional signal and is suitable for investigating in vivo the enzymatic activity.
MRP4 as a new regulator of cyclic nucleotides signalling pathways in the cardiovascular remodeling – AMON
markedly enhanced their signalling effect in vitro and in vivo. We thus show that MRP4 is an important and
Rôle du stress oxydant dans les altérations mitochondriales et/ou le développement de l'insulino-résistance dans le muscle squelettique. – MITOCHROS
activity. Lastly, we will investigate, both in vivo and in vitro, the causative role of ROS in the development
Analysis of the GTPase Rac1 in the arterial system and its implication in the hypertension – GRacArt
arterial pathologies. However, the role of Rac1 in vivo and in the cardiovascular system is still poorly [...] studies investigate the role of Rac1 GTPase in vitro in the vascular smooth muscle and endothelial cells
Huntingtin in Mitosis – HUNIM
of the effects on spindle orientation in vitro and in vivo in Drosophila. [...] we now propose to study huntingtin and mitosis in vivo. We will study huntingtin and spindle orientation [...] Finally, we propose to analyze spindle orientation in vivo in non-neuronal epithelia in Drosophila and mouse
Biogenèse de la poche flagellaire , caractérisation de l’organelle d’endo-exocytose chez Trypanosoma brucei. – Bio-Pocket
BILBO1/2 ' can their interactions be blocked in vitro or in vivo' c). Is BILBO1/2 or their partners exposed [...] primary cilia are not known. We have carried out in vivo RNAi knockdown of BILBO1 RNA transcripts using an
Rôle du récepteur nicotinique dans la dépendance tabagique et le carcinome bronchique – NICOPNEUMOTINE
Institute is a leading laboratory implicated in in vivo studies of nicotinic receptor physiology and function [...] human respiratory epithelium, and in mouse and in vitro models. Combining approaches from both laboratories [...] to express or knock-down (KD) nAChR subunits in vivo. LVs will now be created to express, over-express
Exploration de nouvelles propriétés de macromolécules clés de la traduction mitochondriale humaine – MITOMOT
mitochondrial aminoacylation systems by in vitro approaches, in vivo, decipher the atypical mechanism of g [...] structural and functional characterization (in vitro and in vivo) of a first (of a growing series) splice variant