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Novel perspective for cold plasma application in the repair of infected severe burn wounds – NOVOPLASM
efficacy will be investigated in preclinical in vitro and in vivo models mimicking burn wound infection. The
New Antiviral approach against SARS-CoV2 by Targeting the RNA helicase DHX9, a cofactor of SARS COV-2 – NAT_DHX9
activity spectrum of the optimized compounds in vitro and in vivo. The NAT_DHX9 project ultimately aims to
RNA therapy using antisens oligonucleotides targeting replication and transcription of SARS-CoV-2 – SARS-CoV2 ASO
project is to validate the best ASO firstly by in vitro experiments on infected Vero E6 cultures, and secondly [...] secondly to test the best oligonucleotides antisense in vivo on infected animal model to perform a preclinical
Comparative analysis of anti-SARS-CoV-2 humoral and memory T cell responses in children with various degrees of immunosuppression : a case-control study – PEDIMMCO
detection of specific T cells after ex vivo analysis, in vitro analysis of memory T cells responses will [...] antibodies (pseudovirus neutralization assay). Ex vivo SARS-CoV-2-memory T cell responses will be evaluated
COVID-19 and platelet derived DNA in acute respiratory distress syndrome (ARDS) – PlatdeDNA
The recent and persistent COVID pandemic is adding to the high death toll rate largely due to virus infection induced severe acute respiratory distress syndrome (ARDS) with strong lung inflammation, disruption of the alveolar barrier, acute lung edema, sudden respiratory failure and pulmonary thrombosis. Platelets trigger the thrombotic process and amplify inflammation through interaction with granulocytes generating extracellular dsDNA release, neutrophil extracellular traps, the release of bioactive substances along with the generation of procoagulant platelets in addition to canonical aggregation.
Allergy to COVID-19 Vaccines – ALLCOV
skin testing and ex vivo restimulations. Lastly, we will develop innovative in vitro diagnostic tests to
Development of an instrumented hammer for the estimation of the stability of implants used in orthopedic surgery – OrthoMat
it under various conditions (in silico, in vitro, ex vivo and in anatomical subjects). The originality
MAMs in adipocyte homeostasis and dysfunction – MAMA
metabolic flexibility. WP2 will reveal, both in vitro and in vivo, the effects of the nutritional status on
Adipose tissue-derived progenitors are essential protagonists of Skeletal Muscle Regeneration – ARMURE
realistic project based on a combination of in vitro and ex vivo experiments lying on both mastered and cutting [...] muscle stem cell function in vitro as a prelude start to functional in vivo approaches and then the c [...] different animal models. With these integrated in vivo approaches we expect to show that the transient
Brainstem-spinal circuits for control of locomotor steering. – BSCLS
ical, genetic, and viral-based tools in vitro and in vivo and combine them with the development of a