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Sonoelectrochemical synthesis of calcium phosphate nanoparticles for injectable hydrogels – IXBONE
The treatment of squamous cell carcinomas of the upper aerodigestive tract remains major health challenge (Jemal A, 2011). Treatment is based on wide surgical resectioning combined with external radiation therapy. Moreover, the new radiotherapy technique (IMRT) does not reduce the incidence of Osteoradionecrosis (ORN). Indeed, secondary to ionizing radiation, consequent deleterious effects on bone metabolism and vascularization are responsible for extensive and irreversible bone necrosis.