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Presubicular bursting and visual anchoring of the head direction signal – BURST
How the brain encodes spatial orientation depends strongly on vestibular and visual signals, but the cellular and circuit basis for visual anchoring of the internal compass remains unknown.<br />We will focus on the presubiculum, and the feedback to the lateral mammillary nucleus, that seems to rely on intrinsic bursting neurons of layer 4. Our project evolves around the idea that a burst feedback signal has a key role for visual updating of the head direction signal.
Lab-in-Droplet platform for glycoprotein biomarker discovery: from device conception towards diagnostic applications – DropLab
This Lab-in-Droplet will unprecedentedly offer both efficient sample treatment and resolute analytes separation within sub µL droplets. This will be the first platform able to couple sample treatment and analyte separation modules without any problem of working volume mismatch, thus solving the instrumental and methodological bottlenecks currently encountered in analytical module integration.
Toxicity and mitigation of Versicolorin A, a new fungal mycotoxin – VersiTox
Versicolorin (VerA) is the precursor in the biosynthesis of the toxin Aflatoxin B1 (AFB1). Both molecules are produced in food commodities colonized by fungal species from the Aspergillus genera and so usually co-contaminate food. Whereas AFB1 is a known dangerous toxin for which regulations exist, little is known on the toxicity of VerA. The results of this project are essential for the assessment of the danger associated with the presence of VerA in food.
Capture of the operational Traces of the company’s actors to build human Capital and define the winning Processes – CaTCaP
Learning and evolution of actors' practices, based on individual and collective competencies
Programmable metasurfaces for friction control – Prometaf
Despite centuries of research, the friction of dry macroscopic contact interfaces remains imperfectly understood and thus poorly mastered. Although the optimization of the devices involving functional contacts would enable significant energy savings, there is currently no established method to prepare an interface with pre-defined frictional properties. The aim of PROMETAF is precisely to propose a simple, generic, ground-breaking surface design strategy to obtain such interfaces.
Chirped Pulse And Resonator In one Spectrometer: A novel combined molecular jet chirped pulse/cavity Fourier Transform MicroWave spectrometer for fast scan, high-resolution, and chiral discrimination – PARIS-FTMW
The chirped Pulse And Resonator In one Spectrometer (PARIS) applies an innovative and resource-efficient approach: Using a smart design, most electronic components are used in a dual-purpose spectrometer while almost all vacuum equipment are shared. Therefore, PARIS is built at much lower costs than two individual spectrometers and exceeds the advantages of both techniques individually: Rapid broadband capabilities, intensity reliability, as well as unrivalled resolving power and sensitivity.
Materials with Targeted Responsive Behavior – MataReB
The idea is to develop and use a multi-scale computational and theoretical methodology for the description of stimuli-responsive framework materials with relatively low computational cost.
Cultural participatory platforms. Collaborative creation, documentation and enhancement of cultures and heritage – COLLABORA
In recent years, cultural institutions have shown growing interest in the creation of participatory approaches and in the role that digital technologies could play in their mediation and promotion activities. The COLLABORA project aims to develop a theoretical, empirical and political reflection on new digital platforms contributing to the creation, documentation and promotion of cultures and heritage.
Imaging Spatial and Social Brain Networks in Primates with a “CIM2” approach (Comparative, Immersive, Multimodal and Multicentric) – CIM2
Spatial and social cognitions are two fundamental components of human intelligence, coping with the physical and social dimensions of the environment. Despite extensive efforts, our knowledge of the underlying brain mechanisms is still fragmented and incomplete, and 3 central questions remain largely unanswered:<br />1-What are the brain networks supporting spatial and social cognitions?<br />2-What are the relationships between spatial and social networks?<br />3-What are their specificities in humans?
Cognition and brAin Development in AdolEscents with Tourette Syndrome – CADETS
Adolescence is a sensitive life period that has been suggested to represent a second ‘window opportunity’ in brain development. In children with neurodevelopmental disorders, such as Tourette syndrome (TS) adolescence is usually associated with a reshaping of the clinical symptomatology. The neuronal and cognitive mechanisms associated with TS symptoms improvement during adolescence, or the persistence in adulthood remains unknown, and this is what we aim to address in this proposal.