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The evolution of morphological novelty: from the emergence of a new regulatory function to gene network rewiring – Flyspot
The most obvious aspect of animal diversity is arguably the variation of forms. The evolution of morphological traits is the product of two complementary forces : First, genetic changes generate varia
Role of the nuclear receptor Farnesoid X Receptor (FXR) in energy homeostasis – FXRen
Obesity, defined as an “excess accumulation of fat” by the WHO, reaches “epidemic” proportions worldwide and is a public health problem. Almost 50% of adult people are overweight or obese in France. T
Crosstalks between insulin signaling and lipidome in steatosis – CRISALIS
Nonalcoholic fatty liver disease (NAFLD) is gaining increasing recognition as a component of the epidemic of obesity. NAFLD is the most common cause of liver dysfunction and affects patients worldwide
Expression, function and pathophysiological implications of the mineralocorticoid receptor – EPHIMIR
The mineralocorticoid receptor (MR) is a nuclear receptor whose activity is modulated by aldosterone but also by glucocorticoids. This transcription factor is expressed in polarized epithelia (kidney
Identification of novel genes implicated in structural congenital myopathies by exome sequencing – CM-WES
Rare monogenic diseases are inherited diseases due to defect in a single gene, and target less than 1 in 2,000 people. Taken together, several hundred thousand persons are affected in Europe. Huge pro
Molecular signatures of CKD progression – SIGNA-KID
Understanding the physiopathology of the progression of chronic kidney disease (CKD), a major socioeconomic burden on national health care systems, is a prerequisite for developing efficient preventiv
Networked symbioses adapted to sustainability-oriented urban contexts – SYRACUSE
This programme aims at examining the most promising technological innovations in the field of urban utilities, mainly around issues of symbiosis, convergence and decentralization, and a.t attempting to create an instrument of evaluation of their degree of pertinence according to the context
How to predict moisture disorders? Which technical solutions to renovate the existing building? – HUMIBATex
This project deals with the development of a tool for predicting moisture disorders and proposes technical solutions for renovating the existing building in the form of a technical guide. A simulation platform has been set up. This tool, coupled with existing models, makes it possible to predict the risks of pathologies related to moisture after a renovation.
Targeting of oncogenic microRNAs : toward new chemotherapies – CImiR
One of the most amazing discoveries of the past decade in genetic oncology is that cancer is related not only to alterations of protein coding genes but also to alterations of non-coding RNAs, known as microRNAs (miRNAs). The purpose of this project is the development of small-molecule drugs targeting specific oncogenic miRNAs’ production. This is a very promising approach that would open the way for innovative targeted cancer therapy.
Time-resolved spectroelectrochemistry on 3D-mesoporous electrodes – 3D-BIOELEC
Toward the development of an innovative spectro-electroanalytical methodology allowing characterization of redox biomolecules immobilized on transparent mesoporous metal oxide electrodes.