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Mechanistic evaluation of the interaction between Enterobacteriaceae and fungi in the context of gut inflammation – Enterofun
A previous study of the team allowed us to show that in vivo the presence of Enterobacteria in the intestinal microbiota drastically influenced the effects of fungi on intestinal inflammation. These observations led us to propose a project to study the mechanisms involved in these interactions in order to identify parameters regulating the positive or negative effects of fungi in the gut.
Study of epithelial cell HOMEOstasis disruption in polyCYSTic kidney disease. – Homeocyst
Study of epithelial cell HOMEOstasis disruption in polyCYSTic kidney disease
NGAL, a novel target in Hypertension and associated comorbidities – NGAL-HT
«Our recent exploratory studies identified novel key roles of NGAL (Neutrophil Gelatinase-Associated Lipocalin) in the control of blood pressure. This led to the NGAL-HT consortium associating synergic expertise in pathophysiological research, translational studies and population genetics.
Drug and target discovery for rare retinal dystrophies using patient-derived cellular models – RETINIT-iPS
Inherited retinal dystrophies (IRD) -including Retinitis Pigmentosa (RP) - that cause definitive loss of photoreceptors (PRs), typically result in permanent visual impairment. This study proposes to use patient-derived iPSCs to create advanced cell-based models mimicking photoreceptor degenerative profile observed in RP for drug and target discovery.
primary Antibody ImmunoDeficiencies: genetics and pathophysiological mechanism – AID
Primary antibody deficiencies (PADs) constitute a heterogeneous group of primary immune deficiencies diagnosed in childhood or in adulthood, which remain not well understood. Our project is based on the hypothesis that most B cell immunodeficiencies, e.g. hypogammaglobulinemia, have underlying genetic defects although the latter may be more complex leading to non-Mendelian inheritance pattern.
Functional metabolic mapping of neuronal activation using magnetic resonance – fMETAMR
fMETAMR aims to develop a protocol capable of producing cerebral maps of glucose concentration at rest and glucose concentration changes induced by neuronal activation. Such an approach will complement the traditional functional MRI technique, Blood Oxygenation Level Dependent (BOLD). Combining BOLD with endogenous CEST MRI to detect changes in the concentration of fundamental metabolites, such as glucose, will constitute a powerful tool for the investigation of brain energetics and metabolism.
Autophagy Deficiency in innate immune cells in a paradigm of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) – AD-ME
“Genes x environment” interplays are involved in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We shall focus on genetic autophagy deficiency and exposure to environmental particulate toxins. In the context of a growing vaccine policy, we shall focus on aluminum (Al) adjuvants of vaccines to explain why some people with ME/CFS seemingly intolerant to adjuvants have polymorphic autophagy genes, and how to detect them to limit the risk of adverse effects.
Individual muscle Coordination strategies and their role in the development of musculoskeletal disorders – COMMODE
Our primary testable hypothesis is that each individual has unique muscle coordination strategies that will have specific mechanical effects on his/her MSK system. As such, some strategies would make people more at risk of developing MSK disorders than others.
Deciphering the whole complexity of the Pacific oyster mortality syndrome for modeling epidemiological risk. – DECICOMP
Deciphering the whole complexity of the Pacific oyster mortality syndrome for modeling epidemiological risk.
Adaptation mechanisms in food-fermenting Penicillium fungi – FUNGADAPT
Adaptation mechanisms in food-fermenting Penicillium fungi