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Structural basis of viperin-induced changes in lipid synthesis upon virus infection – VipVir
Lipids are present at every step of the virus life cycle including entry, uncoating, transcription, translation, assemble and egress. They play a crucial role in virus replication and are thus interesting targets for the development of new antiviral strategies. The interferon stimulated genes are part of this strategy and in particular viperin, our protein of interest, seems to interfere with the lipid biosynthesis mechanism.
Resolution of meiotic recombination intermediates from yeast to mouse – Resolve
Meiotic crossovers, necessary for gamete viability, are generated by the cleavage of a precursor recombination intermediate: the double Holliday junction (dHJ), by an uncharacterized meiotic “resolvase”.
Bacterial Cell Remodeling by Viral Infection – BacVirRemodel
Viral infection imposes a major challenge to the host cell. Bacterial viruses (phages or bacteriophages) use a variety of strategies to hijack cellular machineries and to restructure the bacterial cell. This project aims to study the molecular and cellular bases of host takeover used by bacteriophage SPP1 during infection of its host, the Gram-positive bacterium Bacillus subtilis.
Soft Mechatronics: electrostatically driven elastomers – SMArT
Electro-Active Polymers are new soft materials, which may undergo large reversible deformations (tens of percent strains) under an applied electric field, in contrast to piezo-electric ceramics whose
Smart interfaces with thermo-reversible properties – INTHERMO
The INTHERMO project was a project dedicated to academic research, coordinated by the Institut de Science des Matériaux de Mulhouse (ANR JCJC). It started in January 2016 and lasted 45 months.
DESIGN OF ADVANCED STRUCTURED FUNCTIONAL POLYMER SURFACES FROM PHOTO-ACTIVE POLYMER NANOPARTICLES – FUNPOLYSURF
The innovation introduced by FUNPOLYSURF project is the combination of innovative polymer chemistry and the characterization of their passive and active properties to produce novel photo-active coatings with mechanical properties compatible with an application.
Polyoxometallate Materials for Actinide Retreatment – POMAR
This project aims at enhancing purification process currently used in the nuclear industry. The PUREX process used by AREVA and taking place in the industrial unit of la Hague has its own limits regarding the absence of methods available for the recycling of minor actinides and lanthanides in view of potential strategic material economy. Therefore we proposed the use of POMs for their abilities to stabilize the tetravalent oxidation states of actinides cations.
High current CNT cathodes for on-line 3D X-ray inspection – 3DRX-online
The medium term objective of this PCRE project is the development for the industry of low cost stationary RX scanners (without displacement of the source and sensor) for the on-line inspection of mult
A 3D study of the plasticity in deformed polycrystals based on diffraction experiments and crystal-plasticity simulations – 3DPLASTICITY
Strain localization in deformed polycrystalline materials is of major importance for a large number of physical phenomena occurring during the lifetime of a material, such as fatigue, rupture or corrosion cracking. The early state of plastic deformation of a material is of strong interest on the one hand because it is encountered during severe loading conditions, and on the other hand because particularly strong strain heterogeneities occur, as only some grains deform plastically.
Phylogenetic and functional diversity of fungal heme peroxidases – PEROXIDIV
Fungi represent one of the main sources of enzymes used in industry. New peroxidase families (DyPs and UPOs) from fungi have recently emerged for their catalytic versatility and their potential use in diverse industrial domains, from bioremediation to fine chemistry in the pharmaceutical sector