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Cajal-Retzius neurons: from migration in the cerebral cortex to the construction of functional and dysfunctional neural circuits – CRsys
The neocortex controls sensory perception, motor behaviors and cognitive functions. These functions rely on a complex architecture of neural networks that begins to be established during embryonic dev
Interaction of BIN1 and Tau: physiological functions and pathological consequences in Alzheimer’s disease. – BINALZ
To characterize genetic components in AD, we have developed systematic, high-throughput genomic approaches (as part of genome-wide association studies, GWASs) and recently reported the characterization of 21 common genetic determinants of AD, including the bridging integrator 1 gene (BIN1). However, the genetic and molecular mechanisms by which BIN1 affects the AD risk are not known. We have potentially identified BIN1 as the first genetic risk factor for AD linked to tauopathy.
Contribution of astrocytes to hippocampal sharp wave ripples – AstroConRipples
Astrocytes play a key role in cerebral physiology by dynamic interactions with neurons. The project AstroConRipples proposes to elucidate the role of connexin30, a subunit of astroglial gap junction channels involved in cognitive processes, in hippocampal sharp wave ripples.
Non-glycolytic pathways in glycosomes: novel functions for trypanosome development and virulence – GLYCONOV
Trypanosomatids are parasites transmitted by insect vectors responsible for major human diseases, which represent ~24 million infected people worldwide. However, there is no vaccine and few drugs have been developed. The unconventional biological processes developed by these parasites, such as the glycosomal metabolic pathways studied here, are considered potential targets for the development of new drugs. It is in this process that the GLYCONOV project is positioned.
Role of dopamine-glutamate receptor heteromers and downstream nuclear calcium signaling in addiction. – GLAD
The aim of this project is to study molecular, cellular and behavioral responses induced by cocaine with the aim of identifing key targets for the design of novel pharmacological tools for the treatment of addiction.<br /><br />
Understanding the mechanisms of deafness by using intersectional genetics and functional analysis in the mouse – DEAF
With the advent of new molecular genetic tools, particularly in the mouse, studies related to understanding the formation of the auditory system have significantly advanced. Because hearing loss greatly impairs quality of life and leads to a substantial economical cost, understanding the contribution of the different neuronal structures on the sound encoding process will foster the development of new algorithms for hearing aids, cochlear implants, and pharmacological-based therapies.
Pathophysiological Implication of Sumoylation in Intellectual Disability – SUMO-FXS
Fragile X Syndrome (FXS) is the most frequent inherited cause of intellectual disability (ID) but the mechanisms underlying the regulation of FMRP-mediated functions in the brain are still largely unknown. We discovered that FMRP is sumoylated in vivo. Our project will investigate the pathophysiological consequences of FMRP sumoylation in the brain.<br />
Functional study of Heparan suflate for oligodendrogenesis during development and repair – SUGAROLG
Multiple sclerosis is a chronic immune mediated disease most often diagnosed in young adults. Clinical symptoms are related to demyelination of nerve fibers in the central nervous system resulting fro
Study of a putative novel respiratory center – Phox2RESP
This project aims at deciphering the function of a new group of putative respiratory neurons in the hindbrain of the mouse: peri-trigeminal neurons (Peri5). Using genetic tools derived from developmental studies, we will map the connectivity of the Peri5 neurons, target specific mutations to them and characterize their function in reduced ex vivo and in vivo preparations.<br /><br />
Unraveling the properties, regulation and role of AMPAR intracellular transport in synaptic plasticity – PAINT
Plasticity and AMPAR Intracellular Transport