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DEAD-box RNA helicases: in vivo roles, protein partners, RNA substrates and mechanistic details – HeliDEAD
RNA helicases are ubiquitous proteins found in all three kingdoms of life. They are NTP-dependent RNA binding proteins and RNA-dependent NTPases that are associated with all cellular processes involving RNA. Yeast has 45 different RNA helicases that are generally essential and rarely interchangeable, and they are functionally conserved throughout the eukaryotes. Our laboratory is interested in understanding how RNA helicases work, what are their cellular roles and how they are regulated.
Structural and functional study of the MAST2 kinase/PTEN phosphatase interplay, a critical event for neurosurvival. – MAST-2-PTEN
The phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is widely expressed in nervous system, where it inhibits neuronal survival and impedes natural mechanisms of repair. Changes in PTE
Structural and functional investigations of the intrinsically disordered C-terminal domain of ErbB2 – ERBB2CTER
Most previous studies of ErbB2 focused on the extracellular and trans-membrane domains of the protein and yielded an efficient anti-ErbB2 therapy against beast cancer. However, only one-third of ErbB2-positive tumors respond to trastuzumab treatment and those that do acquire resistance within three years after the initiation of treatment. The implication of the C-terminal cytosolic tail of ErbB2 (CtErbB2) in signaling pathways was established but is still poorly understood.
Fine-tuning of translational control through ribosomal RNA methylation: toward the specialized ribosome – RIBOMETH
Deciphering the variable components of the ribosomes contributing to translational regulation.
Nucleation and organization of microtubules by gamma-tubulin complexes – gTuRC
The goal of this project is to understand how microtubule nucleation from gamma-TuRC multiprotein complexes can be activated, and how gamma-TuRCs are anchored to the centrosome, and whether these two aspects can be functionally separated. We want to test the role of accessory proteins that may participate in triggering microtubule nucleation by supporting conformational changes within the gamma-TuRC, and that may play a role in anchoring gamma-TuRCs to microtubule-organizing centres.
Are the conformational dynamics of the ghrelin receptor responsible for its signaling selectivity ? – ghredyn
Are the conformational dynamics of the ghrelin receptor responsible for its functional plasticity ?
Immune and METabolic control in intracellular SYMbiosis of insects – IMetSym
We investigate insect immune and metabolic regulations potentially involved in endosymbiont maintenance and control. We also explore the effects of endosymbionts on insect immune performance.
PARG in Repair, Replication And Transcription – PIRRAT
Our objectives are aimed to decipher the role of the poly(ADP-ribose) degrading enzyme PARG in DNA repair, DNA replication and transcription and to determine the molecular mechanisms involved.
Molecular mechanisms of signal transduction by BvgS, a paradigm for bacterial Venus-flytrap-domain receptors – MECA VENUS
MECA VENUS : Molecular mechanisms of signal perception and transduction by the sensor-kinase BvgS of the two-component system that controls the virulence regulon of the whooping cough agent Bordetella pertussis. BvgS is a model for a family of bacterial receptors with extracytoplasmic, bilobed Venus flytrap perception domains.
Genetic stability in quiescence – quiescenceDNA
How the genetic material is maintained in absence of proliferation is not understood. We want unveils the mutation landscape accumulating during quiescence and study the fate of cells with short telomeres during quiescence