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Adaptive Optics PSF Prediction – APPLY
A critical point when analyzing AO data concerns the separation of the instrument contribution from the intrinsic signature of the astrophysical signal. This can only be achieved by an accurate estimation of the instrument Point Spread Function (PSF). But deriving an accurate PSF model remains a challenge, and the lack of PSF knowledge often represents the main limitation when analyzing AO data.<br />This is the goal of APPLY: provide an accurate PSF model associated with each observation.
Infrared absorption continua: Laboratory studies, calculations and applications to the modeling of the atmospheres of telluric planets – COMPLEAT
Measuring and modeling the IR absorption spectra of H2O, CH4 and H2 mixed with CO2 is of great importance for planetary sciences. These spectra include a contribution due to the local absorption by the rovibrational lines of each species and a broadband contribution (continua) which are poorly characterized but crucial to understand the radiative budget, the composition of planetary atmospheres and to accurately model the formation, evolution, and present atmospheric state of telluric planets.
Enhanced Neutrino Tagging and Energy Reconstruction – ENTER
The project aims at developing a new technique to study neutrino oscillation. So far the properties of the neutrino are measured relying uniquely on the interaction process. We propose to complement these measurements by using the production processes. This extra information would allow to reach unprecedented neutrino energy resolutions. In addition it allows to follow each neutrino from creation to detection and thus removes beam composition uncertainties.
S5: Synchronous Slow Slip & Seismic Swarm – S_5
Catching, modelling and understanding Slow Slip and Seismic Swarms along the Andean subduction in Ecuador, Peru and Chile
Systematics UNcertainties in Combinations of neutrino Oscillation Results – SUNCORE
Neutrino oscillations are, so far, the only example of physics beyond the Standard Model. Such oscillations were first discovered by Super-Kamiokande in 1998 and have been confirmed by a large amount of experiments exploiting neutrinos produced by the Sun, by the Earth atmosphere, by nuclear reactors and by accelerators. <br />Accelerator are particularly powerful nowadays because they allow to observe oscillation of neutrinos and antineutrinos giving access to possible CP violating effects.
A new biphasic microgel as lipoxin delivery system for tissue engineering – BILIPOX
We hypothesize that exogenous provision of LXA4 could dampen excessive inflammation in pulpitis and peridontitis. The specific goal of this project is to evaluate the potential benefits of a new Biphasic Microgel (BPMG) as lipoxin A4 (LXA4) delivery system. This functionalized BPMG aims both to modulate inflammation and to promote tissue repair or regeneration in pulpitis and periodontitis
Targeting D-alanylation of teichoic acids to fight clinically-problematic Gram-positive pathogens – Dalatar
Targeting the D-alanylation of teichoic acids to fight Gram-positive pathogens of clinical interest
Genetic landscape of cardiomyopathies – Landscardio
Cardiomyopathies are an important worldwide public health problem. Available therapies are insufficient. Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, is a neglected disease affecting around 8 million people, with no effective antiparasitic drugs or vaccines. Assessment of rare variants with whole exome sequencing (WES) has disclosed rare heterozygous pathogenic variants in mitochondrial and inflammatory genes associated to CCC cases.
Lipid transport to mitochondria and contact sites formation during phosphate starvation in plants. – MiCoSLiT
The MiCoSLiT project seeks to understand how lipid remodelling occurs in plant mitochondria in response to phosphate starvation and how this remodelling impacst the global resistance of plants to this stress.
Reconstitution of SUMO-dependent organization of the spindle midzone – SUMOzone
The aim of this project is to study how SUMOylation and ubiquitylation control the organization and disassembly of the mitotic spindle midzone. To this end, we will reconstitute a minimal spindle midzone using purified tubulin, and test how SUMO and ubiquitin-dependent pathways of molecular motors and MAPs affect mitotic spindle dynamics.