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Multi-modular Basis of Motor Adaptation and Learning – MultiMod
The cerebellum is a major brain structure with extensive output pathways both descending to motor effectors and ascending to the forebrain. One of its striking features is the organization in multiple specialized modules. Recently, the cerebellum has started to be recognized as a useful target for therapeutic transcranial stimulation. Yet, such empirical procedures are limited by the current lack of knowledge on how the cerebellar functional modules are recruited and coordinate their activity.
Genomic factors underlying the effect of Respiratory Viruses and Allergens in Asthma – NIRVANA
Asthma is a frequent disabling chronic respiratory disease associated with high global costs. For two environmental factors, respiratory allergens and respiratory viruses, strong association with asthma incidence or exacerbations is well documented. A few previous observations suggest that the host genotype plays an important role in the immune response of individual allergens and rhinovirus, but these studies were limited in the assessment of allergen-specific and RV-specific immune responses.
Noncommutative analysis on groups and quantum groups – ANCG
This project deals with noncommutative analysis which is a new research direction emerging from operator spaces, quantum probability and noncommutative harmonic analysis. Fourier and Schur multipliers are at the intersection of these areas. They play a crucial role in recent research motivated by concepts and problems from operator algebras and geometric group theory that we intend to push one step further.
NEOnatal PREcursors of NEurodevelopment – NEOPRENE
For effective therapy of neurodevelopmental disorders, neonatal screening is necessary. The NEOPRENE project proposes that tactile perception and attention are the first foundations of cognitive development and that atypical touch processing at birth exerts a pervasive detrimental influence leading to syndrome-relevant, not syndrome-specific, impairments.
Integration of spinal sensorimotor information in the cerebellar cortex during locomotion – SpinoCereLoco
Our unique approach allows us to break the cycle of the motor command to sensory stimulation into individual components and observe the individual impact of each component on the cerebellum. This will allow us to test the hypothesis that the cerebellar cortex of mammals adapts to cancel the effect of any sensory stimulus that consistently accompanies a motor command and provide an understanding of those mechanisms.
BITTER taste and deTOXification – BITTERTOX
The adaptation to noxious xenobiotics imply not only detoxification mechanisms but also an adaptation of the sensory systems, especially the taste system.
SERS hyperspectral imaging for contaminant detection – HYDRAE
In Hydrae project, we proposed to develop an innovative detection method based on hyperspectral chemical imaging recorded on several optimized SERS-active nanostructured patterns elaborated on the same substrate and to use a statistical analysis of spectral data (chemometrics) to detect and identify the pollutants.
Moduli spaces of Differentials: Flat surfaces and interactions – MoDiff
This project studies new problems of dynamics and geometry on moduli spaces of differentials (also viewed as flat surfaces), by exploring their interactions with combinatorics, enumerative geometry, complex geometry and hyperbolic geometry.
Ultrafast Non Linear Optics in liquid Crystals – UNLOC
The main objective of the UNLOC proposition is the development of a new experimental facility, dedicated to ultrafast nonlinear optics in novel and complex materials. Composed of an energetic femtosecond source, temporal shaping through OPA and/or post-compression systems and adequate spectroscopic tools, it will be devoted to the study of liquid crystals (LC) in two mesophases, and extended to photorefractive materials.
Phase-space GRANULation in fusion plasmas – GRANUL
The efficiency of future fusion reactors, such as tokamaks, depends on our understanding of turbulent processes, in order to control them. In the core of the 150 million degrees plasma, we expect a new kind of turbulence, characterized by the presence of many sub-structures, which trap charged particules.