Search
A Proof-Based Mechanized Plate-Forme for the Verification of B Proof Obligations – BWare
The BWare project is an industrial research project that aims to provide a mechanized framework to support the automated verification of proof obligations coming from the development of industrial app
A library of fluorescent probes to study Reactive Oxygen Species At the Single cell level – ROSAS
Billions of years of photosynthesis have resulted in an oxygen-rich atmosphere in which the respiratory chain and aerobic life could evolve. This allowed the apparition of so-called “superior life for
A new Generation of dRugs for ALzheimer’s disease based on in vitro and in silico experiments of beta-amyloid oligomers and in vivo tests – GRAL
Alzheimer's disease is affecting more than 24 million people worlwide and represents a 1000 billion dollars cost to our society. Thus far, no disease-modifying treatments exist.
A new prototype of fast-heating oven dedicated to roc magnetism investigations – FUReMAG
A new prototype of fast-heating oven dedicated to rock magnetism investigations
A new therapeutic strategy to combat metabolic complications of obesity : the inhibition of fat cell lipolysis – ObeLip
To date, there are 600 million obese individuals worldwide. In France, 14.5% of the adult population is classified as obese. The increase in the number of obese individuals has led to an explosion of
A new tool to deliver epigenetic targeted therapeutics in Multiple Myeloma. – ETTMM (Epigenetic Targeted Treatment of
Identification of biomarkers to predict the sensitivity of myeloma cells to DNMTi and HDACi. <br />Understand the molecular mechanisms associated with the anti-tumor activity of epigenetic-based treatment to define the most efficient therapeutic combinations.
A novel System for the Characterisation of Agregates and Flocs in highly concentrated rivers (SCAF) – SCAF
No instrument can measure fine sediment settling fluxes during flood events. While this variable is of upmost importance for numerical modelling we will develop and apply a System for the Characterisation of Agregates and Flocs (SCAF) in various natural environments and in the laboratory.
A novel model of vascular complications in type I diabetes:new mechanisms and treatments – IN2DN
A novel model of renal lesion in type I diabetes: new mechanisms and treatments.<br />Despite efficient therapies to control glycaemia and blood pressure, still 25-30% of the patients develop DN and macrovascular complications. We believe that one of the major causes of this lack of knowledge is the absence of an animal model cumulating both micro and macrovascular lesions.
A supramolecular balance to measure weak intermolecular interactions – BalanceSupra
We propose to develop a supramolecular balance, which will allow us to detect interactions as weak as 3 J/mol, therefore pushing the present limits by two orders of magnitude. This balance consists of a monomer, which can self-assemble into two cooperative supramolecular structures. The subtle competition between the two forms can easily be monitored and can be tipped one way or the other by the introduction of a weak additional interaction.
A2A receptors and Tauopathy – ADORATAU
The definitive diagnosis of Alzheimer’s Disease (AD) is mostly based on the observation of characteristic brain lesions, usually found during post-mortem examination: ß-amyloid deposits and neurofibri