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A multi-scale view of structure evolution in the Universe – MULTIVERSE
The distribution of matter in today’s Universe exhibits a complex 3-D structure often called the “Cosmic Web”. Our project aims at providing new insight into the physics of structure formation through a multi-scale approach probing the evolution of matter in large structures, from the first assembly of galaxies around the largest over-densities in the initial density field, to the population of groups and clusters comprising today’s cosmic web and the filamentary structures that link them. <br />
A new Fragment-based Approach for inhibition of hk3 and matriptase, two up-regulated serine proteases implicated in tumor progression – FragSPIN
Creation of an experimental pipeline dedicated to the generation of new promising inhibitors of serine protease with therapeutic interest in malignant breast and prostate cancers. The integrated platform combines protease production, parallel inhibitor syntheses and inhibition screening.
A new pH sensor for water resource – SApHIRE
Water quality is appreciated by many physico-chemical parameters including pH which is one of the most used. Technical innovations to reduce the cost and maintenance of these measurement systems are expected to improve the monitoring of water quality from procurement to the release into aquatic ecosystems.
A theoretical investigation of the role of the chemical bond in the Raman and fluorescence response of molecule-semiconductor nanoparticle hybrids – FRAMOLSENT
We will undertake a unified treatment of both fluorescence emission and Raman scattering in a nanosystem consisting of a molecule chemically bound to a nanoparticle or cluster of a metal oxide that be
ADVANCED EXPERIMENTS AND SIMULATIONS OF COMPLEX FLOWS IN TURBOMACHINES – AXIOOM
New regulations about greenhouse gas emissions as well as noise abatement policies require new efficient and accurate optimisation tools for aircraft engine design. A particularly severe cause of loss
AFB1 risk management for a sustainable maïze foodchain – Aflafree
La présence de mycotoxines dans les filières alimentaires est liée au développement de moisissures. Dans ce sens, la limitation de l’application d’antifongiques chimiques à l’horizon 2018 va poser un souci. Le projet propose de trouver un moyen de lutte biologique, à appliquer au champ contre la production d’AFB1 sur le maïs, qui repose sur l’utilisation de bactéries du sol.
ALgorithms and COmplexity for Constraint LANguages – ALCOCLAN
Many computational problems in theoretical computer science can be parametrized in a natural way using so-called constraint languages. A famous example here is the constraint satisfaction problem, b
AMPK an energy sensor involved in male fertility control – FERTiNERGY
In birds and mammals (including humans), nutrition and energy metabolism strongly influence reproduction. In agronomy and more particularly in poultry, the intense selection of chickens for meat produ
AMPc microdomains and structural signaling platforms for the development of retinal projections – MicrocAMP
Intracellular signals are often shared between a large range of signaling pathways. We aim to identify which signals of cAMP, a ubiquitous cellular messenger, participate specifically to the development of the connections between the retina and the brain.