Search
Transposase domestication and epigenetics: Impact on genome dynamics – PIGGYPACK
Transposases mobilize their cognate transposons through specific binding to terminal inverted repeats (TIR) at transposon ends. Domesticated transposase genes have been identified in numerous genomes but whether they serve a cellular function is an open question. This project addresses the question of the part taken by domesticated transposases in programmed genome rearrangements (PGR), using the ciliate Paramecium tetraurelia as a model.
Evolutionary variation of molecular mechanisms controlling epigenetic inheritance in C. elegans – EvolEpiElegans
How environmentally-triggered, non-genetic effects are molecularly transmitted over multiple generations and whether regulation of such epigenetic inheritance shows genetic variation in nature represent key questions in current biological research.
Chromatin function in DNA Double Strand breaks repair: Prime, repair and restore DSB Inducible via AsiSI – DIvA
Over the past few years it has become evident that chromatin, that packages DNA in eukaryotes nuclei and that is encoding epigenetic information, is the real substrate for all DNA related processes and plays a decisive role in DNA repair. Repair into this chromatin context raises several questions that we aim to address in the lab
A genetic survey on sudden cardiac death – GenSuD
Sudden cardiac death (SCD) can be the first symptom of rare inherited arrhythmia disorders. Among these disorders, the Brugada syndrome and the early repolarization syndrome, or ‘J-wave syndromes’ (JWS), are highly amenable to genetic studies and can be used as models to yield molecular insights relevant to the broader problem of SCD.
Manipulation of membrane traffic by bacterial pathogens – Bacterial-Tactics
Cellular traffic is frequently hijacked by intracellular pathogens to invade the cell and replicate. Small GTPases are major regulators of cellular traffic, and are often the target of bacterial toxins. We study the structural and biochemical determinants of bacterial toxins that hijack small GTPases.
Deciphering early and late stages of mammalian mitochondrial Fe-S cluster assembly. – FRATISCA
Iron-sulfur (Fe-S) cluster-containing proteins are essential components of the cell. Within the past decade, the biogenesis of Fe-S proteins has been extensively studied by genetic and biochemical approaches in bacteria and in yeast, and more recently in plants and mammals, demonstrating that it is a complex process involving multiple components. Despite large advances in the field, there are still many important underlying question in order to fully understand this very complex biogenesis.
Biological and synthetic nanostructures investigated by solid-state Nuclear Magnetic Resonance – NanoSSNMR
Supramolecular assemblies of proteins and peptides are ubiquitous in living cells and play key roles in many biological processes. Non-covalent assemblies of protein and peptide subunits form nanostructures such as fibrils, filaments, pores, nanotubes, etc. to execute crucial biological functions (transport across membranes, bacterial secretion, infection, prion propagation, etc.). Determine the atomic architecture of these nanostructures is a technological challenge.
Role of H1 and his partners in the structure and epigenetic properties of chromatin – ChromComp
Our genetic heritage goes far beyond the sequence of our genome. Our development, phenotypical characteristics and cellular functions depend critically on the way the genetic information encoded by DN
Massive Parallelization of STED Nanoscopy to study the fast spatiotemporal orchestration of proteins in cell adhesion – FastNano
Cells adjust their adhesive and cytoskeletal organizations according to changes in the biochemical and physical nature of their surroundings. In return, by adhering and generating forces on neighborin
RNA-protein and Protein-protein interactions within the replication complex of Influenza A Virus – RNAP-IAV
The objective of the collaborative RNAP-IAV project is to understand the molecular mechanisms of human influenza A virus RNP assembly by dissecting the protein-protein and RNA-protein interactions inherent to this intricate architecture and exploiting the resulting structural data to design new antivirals.