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Preclinical validation of hepatocytes derived from pluripotent stem cells for liver biotherapy – StemHepTher
The rationale of our liver-directed regenerative medicine approach is based on clinical trials showing that transplantation of allogeneic human hepatocytes is a safe therapeutic alternative to Liver transplantation. Engrafted hepatocytes improved the clinical outcome of several patients with inborn liver diseases. However, this cell therapy is limited by the shortage of donor liver organs. In addition, isolated hepatocytes cannot be expanded in culture with current methods.
Advanced skin Immunology by omics analysis – ASIO
Finding predictive biomarkers of skin intrusion in maintenance of skin integrity and immune regulation.
Study and inhibition of endothelial cell activation in physiological and pathological retina vascularization – NORMATHER
Retinal vascular diseases (RVD) have been identified as a major cause for blindness worldwide. The first stage of these disorders is characterized by an ischemic event which causes the development of
An innovative therapeutic strategy to treat residual sleepiness in narcolepsy – NarConX
The NarConX project is an industrial research project coordinated by Theranexus. It also associates the Collège de France, INSERM and the Center of Neuroscience Research in Lyon. The project started in October 2014 and lasted 60 months. It benefited from ANR assistance of 924 k€.
RADiosensitizing nanoparticules for therapy against CHONDrosarcoma. A preclinical proof of concept. – CHONDRAD
A preclinical proof of concept
In vivo proof of concept of molecules against hemolytic uremic syndrome – AntiHUS
Shiga toxin-producing Escherichia coli (STEC) infections affect hundreds of thousands of people annually in industrialized countries, including approximately 265,000 people in the United States accord
Biosynthesis of new bioactive molecules by synthetic biology – Mutabiosyntome
Bioactive molecules are essential for human activities such as animal and human health and agriculture. These molecules are either isolated from natural sources (natural products) or synthesised in la
Establishment of cell lines for vaccine viral replication by somatic reprogramming – ECLAIRE
Vaccines production remains one of the biggest challenge for the pharmaceutical industry. Numerous vaccines have been developed over the years but despite important progresses in both standardized and
Systemic injection in the Golden Retriever Muscular Dystrophy dog of a recombinant adeno-associated virus encoding for the canine µdystrophin: Determination of the therapeutic dose that improves skeletal muscle function and cardiac performances. – µdys
- µdys is a program primarily aimed to cure the devastating Duchenne muscular dystrophy (DMD) by expressing a shorter but functional dystrophin polypeptide called “µdystrophin”. DMD is the most freque
Collagen-based composite hydrogels as medicated wound dressings to promote skin wound healing – COLLAG-HEAL
Skin wound healing is impaired in chronic wounds such as foot diabetic ulcers. The absence of wound closure sometimes leads to infection and amputation. Current treatments of skin wounds rely on their