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Analysis of nitric oxide (NO)-based signals in plants challenged by biotic and abiotic stresses – PIANO
1 - Scientific background and objectives Nitric oxide (NO) is a diffusible free radical gas. In animals, NO acts as a signalling molecule in numerous physiological processes. Notably, its biological e
Analysis of the role of the ribosomal mRNA docking site during translation initiation – STIR
The determination of the three-dimensional structure of the prokaryotic ribosome at high resolution has provided vast amounts of information that allows a better understanding of the function of the r
Antigen presenting cells in alloimmune response to factor VIII (FVIII): exploring innovative therapeutics through the molecular dissection of endocytic pathways – ERF8
Hemophilia A is a rare X chromosome-linked recessive disorder that concerns 1/5000 individual. Genetic abnormalities in the FVIII gene result in qualitative or quantitative defects in FVIII production
Antisense sequences delivery for therapeutic intervention on messenger RNAs – GENESPLICE
Up to 50% of disease-associated mutations in humans affect the pre-mRNA splicing and maturation processes, by inactivating splicing signals, creating cryptic ones or modifying binding sites for splici