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A new approach to inhibit ErbB2 signaling and design new drug candidates: targeting the EGF domains of its membrane partner, the MUC4 mucin – DRUG_MUC4
The general goal of the DRUG_MUC4 project is to study the structure-function relationship of the MUC4-ErbB2 complex and propose new small inhibiting therapeutic molecules targeting MUC4-EGF domains.<br />The aberrant overexpression of the transmembrane MUC4 mucin, its partnership with ErbB2 and the negative consequences of the activity of MUC4-ErbB2 complex on epithelial homeostasis, has allowed identification of MUC4 as a highly attractive therapeutic target (Kufe, 2009).
A smart nanotechnology approach for the development of intelligent safety high performance textiles and clothing against chemical warfare agents and pesticides – GraphTEX
Despite the international efforts aimed at regulating and lessening the use of environmentally toxic gas nerve agent, organophosphorus compounds(OP) are still used intensively as pest control agents a
A sociolinguistics of Twitter : social links and linguistic variations – SoSweet
The SoSweet project focuses on the synchronic variation and the diachronic evolution of the variety of French used on Twitter. SoSweet adopts a strong interdisciplinary position, at the crossing of social media linguistics, sociolinguistics, natural language processing (NLP) and network science. It is based on a dataset containing several hundred of millions tweets, together with a several millions users social network.
ACTIVe Reduction Of Aerodynamic Drag. Wake control : from passenger car to long haul vehicle – ACTIV_ROAD
Active Reduction Of Aerodynamic Drag<br />Wake control: from passenger car to long haul vehicle
ADAPTATION OF PHYTOPLANKTON TO POLAR REGIONS: SURVIVAL STRATEGIES DURING THE ARCTIC WINTER – PhytoPol
Phytoplankton is responsible for about half of the photosynthesis on the planet. In polar regions, phototrophic organisms need to survive during long periods of darkness occurring in winter. However s
AErosol RadiatiOn and CLOuds in Southern Africa – AEROCLO-SA
The representation of cloud-aerosol-radiation interaction remain one of the largest uncertainties in climate change, limiting our ability to accurately reconstruct and predict future climate change. In the South East Atlantic, high atmospheric aerosol loadings and semi-permanent stratocumulus cloud are co-located. The area isa unique natural laboratory for studying the full range of aerosol-radiation and aerosol-cloud interactions and their perturbations of the Earth’s radiation budget.
ALIVE: An innovative medical device to improve the diagnostic of liver nodules and liver diseases analysing endogenous fluorescence – ALIVE
Primary liver cancer, including hepatocellular carcinoma (CHC) is the sixth most common cancer in the world with rising incidence. Early and accurate diagnosis is essential for proper management of ca
AN INTEGRATED ELECTRICAL PLASMON NANOSOURCE – INTELPLAN
Plasmonics, or the use of surface plasmon polaritons instead of electrons or photons to convey information in miniaturized circuits, combines the advantages of photonics—its high speed and large bandw