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Microbial serine protease inhibitors against digestive inflammation: new function and therapeutic potential – SerpinGuTarget
Inflammatory Bowel Diseases (IBD) are a group of idiopathic disorders of the gastrointestinal tract (GIT) affecting several millions of people in the world. The incidence of IBD has sharply increased
Mesenchymal and induced pluripotent stem cells for the regenerative medicine of intervertebral disc: the REMEDIV project. – REMEDIV
The intervertebral disc (IVD) is a fibro-cartilage that plays a critical role in spinal kinematics by ensuring the function of "mechanical stress absorber." It consists of a peripheral network of coll
NMDA receptors, Unexpected TargetS in pulmonary arterial hypertension – NUTS
Pulmonary arterial hypertension (PAH) is a rare, severe, and devastating pulmonary vascular disease characterized by chronic increase in pulmonary artery pressure, ultimately leading to right heart fa
Developing a wake and kill radical cure strategy by exploiting the epigenetic control of quiescence of the malaria hypnozoite – HypEpiC
Some malaria parasites, and in particular the highly prevalent Plasmodium vivax in humans, produce hypnozoites that are dormant liver forms that activate months to years after the initial infection to
Inhibition of metallo-ß-lactamases (MBLs) to fight the bacterial resistance to ß-lactam antibiotics – ANTIMBL
Bacterial resistance to antibiotics is a growing threat to public health and endangers the effective treatment of infections. In Europe and other industrialized countries, the highest proportion of re
Post-transcriptional regulation of the heat stress response in plants – HEAT-ADAPT
The capacity of plants to survive exposure to a variety of environmental stresses is of prime importance for food production, especially in the context of global warming. How climatic variations impact plant life cycles is therefore an urgent question to address in order to improve stress tolerance and adapt agriculture to future rises in temperature. This project aim to understand how plants regulate their response to heat stress.
Molecular mechanisms and impact of nonsense mediated mRNA decay on the RNA landscape in eukaryotes – CLEANMD
The “Nonsense mRNA Mediated Decay” (NMD) pathway degrades mRNAs with premature termination codons (PTCs). <br />Two key questions remain unsolved: what distinguishes a PTC from a normal STOP codon and by which mechanisms the recognition of a PTC triggers mRNA degradation? Recent advances obtained within each of the three laboratories of the consortium raised novel hypotheses and methods to address these questions.
INDIVIDUAL CELL SELECTION TO MONITOR THE DYNAMICS OF EPIGENETIC MARKS DURING S-PHASE AND EARLY MAMMALIAN EMBRYOGENESIS. – CELLECTCHIP
Dynamics of epigenetic marks in individual cells<br />
Genome duplication defects caused by homologous recombination deficiency. – StressHoR
Genome Duplication defects caused by homologous recombination deficiency
Genesis and maintenance of bacterial secondary chromosomes – MAGISBAC
The MAGISBAC project aims at providing both a global and detailed view of how secondary replicons adapt to their host and become domesticated in bacteria.