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Dynamics and evolution of yeast genomes, unicellular eukaryotic models. – DYGEVO
Copy number variations play an important role in genome evolution and genetic diseases such as cancer. Using yeast as exprmental model, we study the mechanisms involved. Furthermore, we analyze the role of repetitive elements in the pathogenicity of some yeasts.
A Functional Metagenomic Strategy to decipher Host-Microbiota cross-talk in the Human Intestinal Tract – FunMetaGen
A functional Metagenomic Approach to understand Microbiota Host Crosstalk in the Human Digestive tract. Validation of the effect on Human Health using anipal models and patient cohort.
Oxygen detoxification in anaerobic bacteria : functional genomics and bioenergetics of oxygen reductases – O2StressAnaerob
The presence of membrane-bound oxygen reductase in anaerobic microorganisms is quite intriguing. Studying these systems will bring new mechanistic and evolutive information and will allow us to characterize new antioxidative mechanisms.
Role of NSD/NGD: identification of targets and factors involved in these processes in Saccharomyces cerevisiae – NGD-NSD
Integrity of messenger RNA (mRNA) is essential for a correct translation of the genetic information. Cells have developed mechanisms to degrade defective mRNAs and proteins produced from these mRNAs. Our goal is to better understand these mechanisms and to determine their physiological roles.
The plant TOR pathway: impact on translation – TRANSLATOR
Mecanistic studies of signaling pathways involving the TOR protein and its link with protein synthesis in Arabidopsis thaliana
Sequencing of the oak genome and identification of genes that matter for forest tree adaptation – GENOAK
The research question focuses on understanding the genetic and molecular bases of tree adaptation to their environment, a particularly relevant issue as these perennial organims will have to face with abrupt climate change at the scale of few or a single tree generation!
Plant and Animal Genome Evolution – PAGE
L’accès croissant à la séquence des génomes d’Eucaryotes durant la dernière décennie doit permettre de reconstruire l’histoire des plantes et des animaux au cours de 300-400 millions d’années d’évolution. La comparaison de ces génomes doit permettre de mettre en évidence leur ancêtre commun ainsi que les mécanismes moléculaires ayant donné naissance aux espèces modernes d’intérêt agricole.
Genome Interactions and Malaria transmission Efficiency in Anopheles gambiae – GIME
Our project aims at investigating the impact of the mosquito aquatic environment on its vectorial capacity and particularly the role of bacterial communities present in larval habitats and mosquito midguts.
Repeated evolution of the mouse tooth: an eco-evo-devo perspective – BIGTOOTH
Studies of wild populations of domestic mice evidenced the recurrent evolution of a peculiar dental phenotype (anterior elongation of the tooth, up to the occurrence of an additional cusplet). The project aims at understanding the evolutionary processes and developmental mechanism favoring this striking parallel evolution.
Revisiting the Population Genetics and Genomics of partially clonal organisms – CLONIX
Adapting population Genetics concepts and methods to partial clonality