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Role of the chromatin dynamics on the stochasticity in gene expression in higher eukaryotic cells – STOCHAGENE
Gene expression is an inherently random phenomenon that challenges the view of the cell as a small computer, subjected to the orders of a «genetic program.«
Microbubbles Engineering for Drug Delivery-assisted by Ultrasound – MEDDU
Recent gene therapy clinical studies indicate that its application is not anymore a myth but a reality. Our project aims at developing targeted delivery system based on the use of gaseous microbubbles capable of binding DNA which oscillate by ultrasound on demand. Microbubbles oscillation improve their delivery in tissue located in insonated area. Ultrasound offer the advantage to reach deep organs in non invasive manner.
Nano-sensors for metabolic studies at the single mitochondrion level – NANOMITO
Micro and nanotechnologies are used to design and build systems dedicated to the analysis of oxidative stress. These systems provide the monitoring of activities of individual mitochondria, in order to go further into the understanding of mitochondrial pathologies.
Mechanism of inhibition of a novel target of beta-lactam antibiotics – CarbaTub
Emergence of resistance to multiple antibiotics requires the indentification and chartacterization of new targets for drug developement. The aim of our project is to characterize a promising target for the tretament of multidrug resistant tuberculosis
FRET biosensors for spatio-temporal dynamic kinase activity by fast FLIM and fluorescence anisotropy microscopy – KinBioFRET
We propose to develop new FRET biosensors to measure the activity of two essential mitotic kinases, MELK and Aurora A, in the frame of spatio-temporal regulation of these kinases during cell division in living genetically tractable model organisms.
Nano-reinforced hydrogel for cartilage regenerative medicine and tissue engineering – HYCAR
Current hydrogels, scaffold for stem cells or cells from cartilage tissue are too fragile to regenerate cartilage because they are too hydrated or do not allow the life of cells, because they are too dense. the use of nano-reinforcements must allow us to improve the mechanical properties of these scaffolds without altering biology of cells.
Mathematical and Physical Modeling of Regenerative Repair – REGENR
Mathematical and Physical Modeling of Regenerative Repair
Characterization of a radical DNA repair enzyme: the spore photoproduct lyase – SPOREPAIR
Bacterial spores are dormant forms adopted by some bacteria under stress conditions. Specific features of spores include a high degree of dehydration, the compaction of the genome in a core protected
Controlling photobleaching of fluorescent proteins for super-resolution microscopy. – NOBLEACH
This research will serve the development of modern biological fluorescence microscopy by engineering better fluorescence markers.
Active and passive mechanics of the mechanosensory hair-cell bundle along the tonotopic axis of the mammalian cochlea. – EARMEC
Our hearing is sensitive to sound frequencies that vary by one thousandfold - from 20Hz to 20kHz, while discriminating frequencies that differ by only 0.2%. The cochlea is endowed with mechano-sensory hair cells that each respond to a well-defined frequency of the auditory range by a mechanism that we propose to clarify.