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Neural mechanisms of vocal learning in songbird: role of the basal ganglia – SONGLEARN
Vocal learning involves the basal ganglia (BG)-thalamo-cortical network, as do many other complex motor skills. I propose to study the role of the BG-thalamo-cortical loop in sensorimotor learning, fo
Radical Events and Life Reconstruction (anthropological approach in the context of India) – RUPTURES
People can have their lives utterly and irreversibly modified by events, such as illness, accident or experience of violence, and so embark on reconstructing them thus experimenting new possibilities and conditions of being-in-the-world.
Role of 5-Fluorouracil in the modulation of anticancer immune responses: Molecular mechanisms and identification of novel therapeutic targets – RFAT
Accumulating evidence indicates that the immune system makes a crucial contribution to the antitumor effects of conventional chemotherapy-based cancer treatments. However, the tumor-mediated immunosuppression of the host limits the initiation of anticancer immunity. We aim to document how some anticancer agents can relieve the host immunosuppression to unleash an immune response that eradicates residual tumor cells.
Response of Corals to Local and Global Stressors: from gametes to adults – R-ECOLOGS
Scleractinian corals, which serve as structural elements of the reef and provide a habitat to many important fish and reef species, play a key role in maintaining the marine biodiversity present in coral reefs. Unfortunately today, the whole coral life cycle is threatened by local and global stressors, acting individually or in combination. A better understanding on coral responses to local and global stressors is critical to improve locally the conservation of coral biodiversity.
Quantum Nano-Optomechanics – Q-NOM
The long term goal of the QNOMproject is to explore the system made of a mechanical oscillator and a two level system and to clear the way for a long term exploration of this new kind of fundamental hybrid systems. <br />
Observing functional protein dynamics at atomic resolution by solid-state NMR spectroscopy – ProtDynByNMR
Development of new solid-state NMR methods and application to the understanding of function-motion relationship in biologically important target proteins
Carbon monoxide/heterocycle copolymerisation: New catalysts and new biodegradable polymers – NewCatNewBioPol
The demand of synthetic biodegradable polymers as alternative environmentally friendly polymers compared to polyolefins, increases regularly. The main problem of such polymers being their high synthetic cost. The metal-catalysed alternative copolymerization of heterocycles and carbon monoxide is a synthetic route of choice for the synthesis of such material from cheap and available monomers. Unfortunately, few efficient catalyst systems have been described yet.
Modeling and therapeutic approaches of liver inherited disorders with patient-specific iPS cells – Liv-iPS
La transplantation d’hépatocytes est maintenant une alternative à la greffe orthotopique du foie pour le traitement des maladies métaboliques sévères. Cependant la pénurie d’organes transplantables s’
Pre-clinical assessment of pluripotent stem cell therapy for Huntington’s disease – HD-SCT
Biotherapies based on the use of human pluripotent stem cells (hPSC) hold great promise for regnerative medicine. HD-SCT (HD-Stem Cell Therapy) deals with the thorough evaluation of the potential of hPSC as an efficient, safe and clinically relevant cellular source for Huntington disease therapy.
hematopoietic STem cell REtention upon Affinity and Mechanical properties – STREAM
The frame of the STREAM project is focused on the most achieved field of cell therapy: Hematopoietic Stem Cells (HSC) Transplantation for bone marrow reconstitution in patients with malignant hemopath