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A forgotten tradition: French Socialist intellectuals and reformers 1830-1870 – UTOPIES19
Socialist Reformers and Reform (France, 1815-1851).<br />The UTOPIES19 project focuses on the works of the French “utopian” socialists from the first half of the 19th century. It aims to study not just competing socialist theories but also attempts to put into practice ideas for reforming existing social arrangements.
A humanised mouse expressing a human class I and class II HLA gene and the human insulin gene as a preclinical model for human type 1 diabetes. – YES
Aims. Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic ß-cells. The HLA DQB1*0302 class II HLA gene carry the highest risk for T1D, but class I MHC alleles modulate the risk
A key enzyme in nucleic acid biosynthesis : The 5’-cytosolic nucleotidase (cN-II) as new drug target – cN-II Focus
Our main objective is to study an enzymatic system that have been shown to be involved in resistance mechanisms to cytotoxic nucleoside analogues, thus aiming to improve the efficacy of such family of derivatives used in cancer chemotherapy.
A multi-scale view of structure evolution in the Universe – MULTIVERSE
The distribution of matter in today’s Universe exhibits a complex 3-D structure often called the “Cosmic Web”. Our project aims at providing new insight into the physics of structure formation through a multi-scale approach probing the evolution of matter in large structures, from the first assembly of galaxies around the largest over-densities in the initial density field, to the population of groups and clusters comprising today’s cosmic web and the filamentary structures that link them. <br />
A new Fragment-based Approach for inhibition of hk3 and matriptase, two up-regulated serine proteases implicated in tumor progression – FragSPIN
Creation of an experimental pipeline dedicated to the generation of new promising inhibitors of serine protease with therapeutic interest in malignant breast and prostate cancers. The integrated platform combines protease production, parallel inhibitor syntheses and inhibition screening.
A new pH sensor for water resource – SApHIRE
Water quality is appreciated by many physico-chemical parameters including pH which is one of the most used. Technical innovations to reduce the cost and maintenance of these measurement systems are expected to improve the monitoring of water quality from procurement to the release into aquatic ecosystems.
A theoretical investigation of the role of the chemical bond in the Raman and fluorescence response of molecule-semiconductor nanoparticle hybrids – FRAMOLSENT
We will undertake a unified treatment of both fluorescence emission and Raman scattering in a nanosystem consisting of a molecule chemically bound to a nanoparticle or cluster of a metal oxide that be
ADVANCED EXPERIMENTS AND SIMULATIONS OF COMPLEX FLOWS IN TURBOMACHINES – AXIOOM
New regulations about greenhouse gas emissions as well as noise abatement policies require new efficient and accurate optimisation tools for aircraft engine design. A particularly severe cause of loss
AFB1 risk management for a sustainable maïze foodchain – Aflafree
La présence de mycotoxines dans les filières alimentaires est liée au développement de moisissures. Dans ce sens, la limitation de l’application d’antifongiques chimiques à l’horizon 2018 va poser un souci. Le projet propose de trouver un moyen de lutte biologique, à appliquer au champ contre la production d’AFB1 sur le maïs, qui repose sur l’utilisation de bactéries du sol.